Bronchiolitis obliterans

Luis Angel, Arturo Homma, Stephanie M Levine

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Bronchiolitis obliterans (BO) is a fibrotic lung disease involving the small conducting airways. BO may be classified by etiology and underlying disease or, more commonly, by histopathological pattern. The two major histopathological categories are (1) BO organizing pneumonia (BOOP) and proliferative bronchiolitis and (2) constrictive bronchiolitis. The former is often idiopathic in nature and may also be associated with connective tissue diseases and inhalation injury. Characteristic findings on chest imaging include alveolar infiltrates and ground glass opacities and pulmonary function tests (PFTs) usually reveal restrictive dysfunction. Constrictive bronchiolitis is associated with organ transplantation, infections, connective tissue diseases, inhalation injury, and drugs and may also have an idiopathic origin. The radiographic characteristic is a mosaic pattern on high-resolution computed tomography (HRCT) and PFTs most often reveal obstructive dysfunction. This article will attempt to review constrictive BO, including histopathology, clinical presentation, radiographic appearance, and physiological findings, for both idiopathic diseases, as well as specific clinical-associated entities.

Original languageEnglish (US)
Pages (from-to)123-134
Number of pages12
JournalSeminars in Respiratory and Critical Care Medicine
Volume21
Issue number2
StatePublished - 2000

Fingerprint

Bronchiolitis Obliterans
Connective Tissue Diseases
Respiratory Function Tests
Inhalation Administration
Cryptogenic Organizing Pneumonia
Wounds and Injuries
Organ Transplantation
Inhalation
Lung Diseases
Glass
Thorax
Tomography
Infection

Keywords

  • Bone marrow transplantation
  • Bronchiolitis obliterans
  • Constrictive bronchiolitis
  • Lung transplantation
  • Panbronchiolitis

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Pulmonary and Respiratory Medicine
  • Critical Care

Cite this

Bronchiolitis obliterans. / Angel, Luis; Homma, Arturo; Levine, Stephanie M.

In: Seminars in Respiratory and Critical Care Medicine, Vol. 21, No. 2, 2000, p. 123-134.

Research output: Contribution to journalArticle

Angel, L, Homma, A & Levine, SM 2000, 'Bronchiolitis obliterans', Seminars in Respiratory and Critical Care Medicine, vol. 21, no. 2, pp. 123-134.
Angel, Luis ; Homma, Arturo ; Levine, Stephanie M. / Bronchiolitis obliterans. In: Seminars in Respiratory and Critical Care Medicine. 2000 ; Vol. 21, No. 2. pp. 123-134.
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