Two nonsteroidal anti-inflammatory agents greatly reduced, but did not completely suppress, tumor promotion in mouse skin by the croton oil factor 12-0-tetradec-anoy(phorbo(-13-acetate (TPA). The ^steroidal anti-inflammatory agent dexamethasone, which previously completely suppressed TPApromotion, markedly reduced tumor initiationby 3-methylcholanthrene (MCA), and reducedcomplete carcinogenesis by MCA. Theinhibition of initiation appeared to be substantially greater than that obtained previouslywith other agents and suggested that dexamethasone may be a valuable tool for thestudy of events in tumor initiation. The resultsalso suggested that only a small part of thecarcinogenic potency of MCA was due to promotion of the type brought about by TPA.—J Natl Cancer Inst.
ASJC Scopus subject areas
- Cancer Research