Brief communication:inhibition of tumor initiation and promotion by antiinflammatory agents12

Thomas J. Slaga, John D. Scribner

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


Two nonsteroidal anti-inflammatory agents greatly reduced, but did not completely suppress, tumor promotion in mouse skin by the croton oil factor 12-0-tetradec-anoy(phorbo(-13-acetate (TPA). The ^steroidal anti-inflammatory agent dexamethasone, which previously completely suppressed TPApromotion, markedly reduced tumor initiationby 3-methylcholanthrene (MCA), and reducedcomplete carcinogenesis by MCA. Theinhibition of initiation appeared to be substantially greater than that obtained previouslywith other agents and suggested that dexamethasone may be a valuable tool for thestudy of events in tumor initiation. The resultsalso suggested that only a small part of thecarcinogenic potency of MCA was due to promotion of the type brought about by TPA.—J Natl Cancer Inst.

Original languageEnglish (US)
Pages (from-to)1723-1725
Number of pages3
JournalJournal of the National Cancer Institute
Issue number5
StatePublished - Nov 1973
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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