Breast- vs formula-feeding affects postweaning cholesteryl ester transfer activity and hdl-c subfraction levels in baboons

A. Van Toi E, M. Jackson, C. A. McMahan, G. E. Mott

Research output: Contribution to journalArticle

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Abstract

To determine the metabolic basis of dietary programming of HDL concentrations by infant diet we measured serum lipid transfer activities at 97 weeks of age in 35 baboons. Breast-fed and formulafed baboons were fed a high cholesterol, saturated fat diet after weaning at 15 weeks, cholesterol ester transfer protein (CETP), phospholipid transfer protein (PLTP), and lecithin cholesterol acyl-transferase (LCAT) were measured using exogenous substrates and HDL subfractions were isolated by ultracentrifugation. Among breast-fed baboons CETP activity at 97 weeks was 16% higher (P < 0.075) and LCAT was 10% lower (P < 0.09) compared with those fed formula. PLTP activity did not differ by infant diet. HDLl-cholesterol (C) was 22% lower, HDL2-C 13% lower, and HDL3-C 17% lower among breast-fed compared with formula-fed baboons. HDL1-C and HDL3-C were negatively correlated with CETP activity fr = -0.33, P = 0.08 and r = -0.32. P = 0.09 respectively). We conclude that postweaning differences in CETP and LCAT activities may mediate the differences in HDL-C fractions of breast- vs formula-fed baboons. Supported by the American Heart Association, Texas Affiliate grant #94G-356, and NIH Grant ROI HD 24308.

Original languageEnglish (US)
JournalFASEB Journal
Volume10
Issue number3
StatePublished - 1996

Fingerprint

bottle feeding
cholesteryl ester transfer protein
cholesteryl esters
Papio
Cholesterol Esters
Cholesterol Ester Transfer Proteins
breasts
phosphatidylcholine-choline acyltransferase
Breast
Cholesterol
feed formulation
Lecithins
Nutrition
Transferases
Phospholipid Transfer Proteins
Diet
cholesterol
diet
ultracentrifugation
Organized Financing

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Breast- vs formula-feeding affects postweaning cholesteryl ester transfer activity and hdl-c subfraction levels in baboons. / Van Toi E, A.; Jackson, M.; McMahan, C. A.; Mott, G. E.

In: FASEB Journal, Vol. 10, No. 3, 1996.

Research output: Contribution to journalArticle

Van Toi E, A. ; Jackson, M. ; McMahan, C. A. ; Mott, G. E. / Breast- vs formula-feeding affects postweaning cholesteryl ester transfer activity and hdl-c subfraction levels in baboons. In: FASEB Journal. 1996 ; Vol. 10, No. 3.
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AU - Mott, G. E.

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