Breast- vs formula-feeding affects postweaning cholesteryl ester transfer activity and hdl-c subfraction levels in baboons

A. Van Toi E, M. Jackson, C. A. McMahan, G. E. Mott

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

To determine the metabolic basis of dietary programming of HDL concentrations by infant diet we measured serum lipid transfer activities at 97 weeks of age in 35 baboons. Breast-fed and formulafed baboons were fed a high cholesterol, saturated fat diet after weaning at 15 weeks, cholesterol ester transfer protein (CETP), phospholipid transfer protein (PLTP), and lecithin cholesterol acyl-transferase (LCAT) were measured using exogenous substrates and HDL subfractions were isolated by ultracentrifugation. Among breast-fed baboons CETP activity at 97 weeks was 16% higher (P < 0.075) and LCAT was 10% lower (P < 0.09) compared with those fed formula. PLTP activity did not differ by infant diet. HDLl-cholesterol (C) was 22% lower, HDL2-C 13% lower, and HDL3-C 17% lower among breast-fed compared with formula-fed baboons. HDL1-C and HDL3-C were negatively correlated with CETP activity fr = -0.33, P = 0.08 and r = -0.32. P = 0.09 respectively). We conclude that postweaning differences in CETP and LCAT activities may mediate the differences in HDL-C fractions of breast- vs formula-fed baboons. Supported by the American Heart Association, Texas Affiliate grant #94G-356, and NIH Grant ROI HD 24308.

Original languageEnglish (US)
Pages (from-to)A552
JournalFASEB Journal
Volume10
Issue number3
StatePublished - Dec 1 1996

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

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