Breast cancer in pregnancy: A literature review

Junda C. Woo, Taechin Yu, Thelma C. Hurd

Research output: Contribution to journalReview articlepeer-review

209 Scopus citations

Abstract

Hypothesis: Breast cancer in pregnancy will increase as more women postpone childbearing until later in life. Objective: To review the literature on diagnosis, staging, treatment, and prognosis. Design and Methods: Articles were obtained from MEDLINE (1966-present) using the keywords breast, cancer, carcinoma, and pregnancy. Additional articles were sought using the references of those obtained. A total of 171 articles were found, 125 in English. More than 100 were reviewed, including 7 prospective and 40 retrospective studies, 6 case reports, and at least 47 review articles on various aspects of pregnancy and cancer. Data extraction was performed by 1 reviewer. Results: Diagnostic delays are shorter than in the past but remain common. Mammography has a high false-negative rate during pregnancy. Biopsy or needle aspiration are needed for diagnosis and cannot be postponed until after delivery. Pregnancy-associated cancers tend to occur at a later stage and be estrogen receptor-negative. However, they carry a similar prognosis to other breast cancers when matched for stage and age. Although modified radical mastectomy is the traditional treatment, breast-conserving therapy is increasingly common. Therapeutic radiation is contraindicated, but chemotherapy is relatively safe after the first trimester. Tamoxifen should be avoided in the first trimester and possibly beyond. Conclusions: Physicians should perform a thorough breast examination at the first prenatal visit and maintain a high index of suspicion for cancer. Patients who wish to continue their pregnancies have a growing array of treatment options.

Original languageEnglish (US)
Pages (from-to)91-98
Number of pages8
JournalArchives of Surgery
Volume138
Issue number1
DOIs
StatePublished - Jan 1 2003

ASJC Scopus subject areas

  • Surgery

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