Breast and thyroid cancer: A multicenter study with Accrual to Clinical Trials Network

Merry Peckham; Horace J. Spencer; Shorabuddin Syed; William B. Armstrong; Donald Gregory Farwell; Thomas J. Gal; David Goldenberg; Marika D. Russell; Roberto N. Solis; Deanne King; Brendan C. Stack

doi:10.1002/jso.26825

Breast and thyroid cancer: A multicenter study with Accrual to Clinical Trials Network

Merry Peckham, Horace J. Spencer, Shorabuddin Syed, William B. Armstrong, Donald Gregory Farwell, Thomas J. Gal, David Goldenberg, Marika D. Russell, Roberto N. Solis, Deanne King, Brendan C. Stack

Department of Population Health Sciences

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Objective: To investigate a possible link between breast and thyroid cancer. Methods: A multicenter retrospective review of patients in the electronic medical records of six Accrual to Clinical Trial (ACT) institutions with both breast cancer and thyroid carcinoma. Each center queried its data using a predefined data dictionary. Information on thyroid and breast cancer included dates of diagnosis, histology, and patient demographics. Results: A random-effects model was used. There were 4.24 million women's records screened, 44 605 with breast cancer and 11 846 with thyroid cancer. The relative risks observed at each institution ranged from 0.49 to 13.47. The combined risk ratio (RR) estimate was 1.77 (95% confidence interval: 0.50–5.18). Conclusion: There was no association between the risk of developing thyroid cancer and being a breast cancer survivor compared to no history of breast cancer, but the range of relative risks among the participating institutions was wide. Our findings warrant further study of more institutions with larger sample size. Additionally, further analysis of the significance of regional RR differences may be enlightening.

Original language	English (US)
Pages (from-to)	1211-1217
Number of pages	7
Journal	Journal of Surgical Oncology
Volume	125
Issue number	8
DOIs	https://doi.org/10.1002/jso.26825
State	Published - Jun 15 2022

Keywords

breast cancer
epidemiology
thyroid cancer

ASJC Scopus subject areas

Surgery
Oncology

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10.1002/jso.26825

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title = "Breast and thyroid cancer: A multicenter study with Accrual to Clinical Trials Network",

abstract = "Objective: To investigate a possible link between breast and thyroid cancer. Methods: A multicenter retrospective review of patients in the electronic medical records of six Accrual to Clinical Trial (ACT) institutions with both breast cancer and thyroid carcinoma. Each center queried its data using a predefined data dictionary. Information on thyroid and breast cancer included dates of diagnosis, histology, and patient demographics. Results: A random-effects model was used. There were 4.24 million women's records screened, 44 605 with breast cancer and 11 846 with thyroid cancer. The relative risks observed at each institution ranged from 0.49 to 13.47. The combined risk ratio (RR) estimate was 1.77 (95% confidence interval: 0.50–5.18). Conclusion: There was no association between the risk of developing thyroid cancer and being a breast cancer survivor compared to no history of breast cancer, but the range of relative risks among the participating institutions was wide. Our findings warrant further study of more institutions with larger sample size. Additionally, further analysis of the significance of regional RR differences may be enlightening.",

keywords = "breast cancer, epidemiology, thyroid cancer",

author = "Merry Peckham and Spencer, {Horace J.} and Shorabuddin Syed and Armstrong, {William B.} and Farwell, {Donald Gregory} and Gal, {Thomas J.} and David Goldenberg and Russell, {Marika D.} and Solis, {Roberto N.} and Deanne King and Stack, {Brendan C.}",

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year = "2022",

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doi = "10.1002/jso.26825",

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AU - Peckham, Merry

AU - Spencer, Horace J.

AU - Syed, Shorabuddin

AU - Armstrong, William B.

AU - Farwell, Donald Gregory

AU - Gal, Thomas J.

AU - Goldenberg, David

AU - Russell, Marika D.

AU - Solis, Roberto N.

AU - King, Deanne

AU - Stack, Brendan C.

PY - 2022/6/15

Y1 - 2022/6/15

N2 - Objective: To investigate a possible link between breast and thyroid cancer. Methods: A multicenter retrospective review of patients in the electronic medical records of six Accrual to Clinical Trial (ACT) institutions with both breast cancer and thyroid carcinoma. Each center queried its data using a predefined data dictionary. Information on thyroid and breast cancer included dates of diagnosis, histology, and patient demographics. Results: A random-effects model was used. There were 4.24 million women's records screened, 44 605 with breast cancer and 11 846 with thyroid cancer. The relative risks observed at each institution ranged from 0.49 to 13.47. The combined risk ratio (RR) estimate was 1.77 (95% confidence interval: 0.50–5.18). Conclusion: There was no association between the risk of developing thyroid cancer and being a breast cancer survivor compared to no history of breast cancer, but the range of relative risks among the participating institutions was wide. Our findings warrant further study of more institutions with larger sample size. Additionally, further analysis of the significance of regional RR differences may be enlightening.

AB - Objective: To investigate a possible link between breast and thyroid cancer. Methods: A multicenter retrospective review of patients in the electronic medical records of six Accrual to Clinical Trial (ACT) institutions with both breast cancer and thyroid carcinoma. Each center queried its data using a predefined data dictionary. Information on thyroid and breast cancer included dates of diagnosis, histology, and patient demographics. Results: A random-effects model was used. There were 4.24 million women's records screened, 44 605 with breast cancer and 11 846 with thyroid cancer. The relative risks observed at each institution ranged from 0.49 to 13.47. The combined risk ratio (RR) estimate was 1.77 (95% confidence interval: 0.50–5.18). Conclusion: There was no association between the risk of developing thyroid cancer and being a breast cancer survivor compared to no history of breast cancer, but the range of relative risks among the participating institutions was wide. Our findings warrant further study of more institutions with larger sample size. Additionally, further analysis of the significance of regional RR differences may be enlightening.

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KW - epidemiology

KW - thyroid cancer

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Breast and thyroid cancer: A multicenter study with Accrual to Clinical Trials Network

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