Breakthrough invasive fungal infections: Who is at risk?

Jeffrey D. Jenks, Oliver A. Cornely, Sharon C.A. Chen, George R. Thompson, Martin Hoenigl

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations


The epidemiology of invasive fungal infections (IFIs) in immunocompromised individuals has changed over the last few decades, partially due to the increased use of antifungal agents to prevent IFIs. Although this strategy has resulted in an overall reduction in IFIs, a subset of patients develop breakthrough IFIs with substantial morbidity and mortality in this population. Here, we review the most significant risk factors for breakthrough IFIs in haematology patients, solid organ transplant recipients, and patients in the intensive care unit, focusing particularly on host factors, and highlight areas that require future investigation.

Original languageEnglish (US)
Pages (from-to)1021-1032
Number of pages12
Issue number10
StatePublished - Oct 1 2020


  • breakthrough fungal infections
  • fungal infections
  • risk factors

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases


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