BRCA1 in clinical breast cancer

C. Kent Osborne; Richard M. Elledge; Powel H. Brown; Susan G. Hilsenbeck

doi:10.3233/BD-1998-101-210

BRCA1 in clinical breast cancer

C. Kent Osborne, Richard M. Elledge, Powel H. Brown, Susan G. Hilsenbeck

Medicine

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

It should be clear from this review that most, if not all, questions raised at the beginning have only partial answers at best. Significant gaps remain and must await greater understanding of the biological effects of BRCA1 and BRCA2 alterations; the natural history of molecularly defined mutation-associated breast cancer; and the effects of currently proposed prevention and treatment strategies. In this regard, pediatric oncology may provide a useful paradigm. Tremendous advances can be made, even in very rare diseases, by population-wide inclusion of at-risk individuals in standardized management protocols and rigorous collection of associated outcome data.

Original language	English (US)
Pages (from-to)	77-88
Number of pages	12
Journal	Breast Disease
Volume	10
Issue number	1-2
DOIs	https://doi.org/10.3233/BD-1998-101-210
State	Published - Apr 1998

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "BRCA1 in clinical breast cancer",

abstract = "It should be clear from this review that most, if not all, questions raised at the beginning have only partial answers at best. Significant gaps remain and must await greater understanding of the biological effects of BRCA1 and BRCA2 alterations; the natural history of molecularly defined mutation-associated breast cancer; and the effects of currently proposed prevention and treatment strategies. In this regard, pediatric oncology may provide a useful paradigm. Tremendous advances can be made, even in very rare diseases, by population-wide inclusion of at-risk individuals in standardized management protocols and rigorous collection of associated outcome data.",

author = "Osborne, {C. Kent} and Elledge, {Richard M.} and Brown, {Powel H.} and Hilsenbeck, {Susan G.}",

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AU - Osborne, C. Kent

AU - Elledge, Richard M.

AU - Brown, Powel H.

AU - Hilsenbeck, Susan G.

PY - 1998/4

Y1 - 1998/4

N2 - It should be clear from this review that most, if not all, questions raised at the beginning have only partial answers at best. Significant gaps remain and must await greater understanding of the biological effects of BRCA1 and BRCA2 alterations; the natural history of molecularly defined mutation-associated breast cancer; and the effects of currently proposed prevention and treatment strategies. In this regard, pediatric oncology may provide a useful paradigm. Tremendous advances can be made, even in very rare diseases, by population-wide inclusion of at-risk individuals in standardized management protocols and rigorous collection of associated outcome data.

AB - It should be clear from this review that most, if not all, questions raised at the beginning have only partial answers at best. Significant gaps remain and must await greater understanding of the biological effects of BRCA1 and BRCA2 alterations; the natural history of molecularly defined mutation-associated breast cancer; and the effects of currently proposed prevention and treatment strategies. In this regard, pediatric oncology may provide a useful paradigm. Tremendous advances can be made, even in very rare diseases, by population-wide inclusion of at-risk individuals in standardized management protocols and rigorous collection of associated outcome data.

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JO - Breast Disease

JF - Breast Disease

SN - 0888-6008

IS - 1-2

ER -

BRCA1 in clinical breast cancer

Abstract

ASJC Scopus subject areas

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