BRCA1, hormone, and tissue-specific tumor suppression

Yanfen Hu

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations

Abstract

Germline mutations of BRCA1 predispose women to breast and ovarian cancers. Elucidating molecular mechanism of tissue- and gender-specific phenomena in BRCA1-related tumors is a key to our understanding of BRCA1 function in tumor suppression. This review summarizes studies in recent years on the link between BRCA1 and estrogen/progesterone signaling pathways, as well as discusses various models underscoring a triangle relationship among BRCA1, estrogen and genome instability.

Original languageEnglish (US)
Pages (from-to)20-27
Number of pages8
JournalInternational Journal of Biological Sciences
Volume5
Issue number1
DOIs
StatePublished - 2009

Keywords

  • BRCA1
  • Estrogen
  • Genome instability
  • Tumor suppression

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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