Branched-Chain Amino Acids Depletion during Hemodialysis Is Associated with Fatigue

Subrata Debnath, Carlos Lorenzo, Shweta Bansal, Juan Morales, Rain O. Rueda, Balakuntalam S. Kasinath, Kumar Sharma, Jason C. O'Connor

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Fatigue is one of the most debilitating symptoms reported by maintenance hemodialysis (MHD) patients. Hemodialysis causes marked depletion in plasma essential amino acids. We studied the cross-sectional relationship of pre- and post-hemodialysis branched-chain amino acids (BCAAs) concentrations with fatigue in MHD patients. Methods: MHD patients self-reported fatigue during a dialysis session using the Brief Fatigue Inventory. Pre- and post-dialysis plasma levels of BCAAs (valine, leucine, and isoleucine) were measured using HPLC-mass spectrometry. Results: The mean age of study participants (n = 114) was 54.8 ± 12.8 years. Plasma levels of BCAAs decreased significantly post-dialysis compared to pre-dialysis (303.8 ± 9.4 vs. 392.1 ± 9.4 μM/L, p < 0.0001). Fatigue score increased as a function of age (p = 0.015). There was no association between pre-dialysis plasma levels of BCAAs and fatigue. A significant negative correlation was found between post-dialysis plasma levels of BCAAs and fatigue (p < 0.05). Conclusions: These preliminary findings suggest that disruption in BCAAs homeostasis may play a role in precipitating fatigue.

Original languageEnglish (US)
Pages (from-to)565-571
Number of pages7
JournalAmerican journal of nephrology
Volume51
Issue number7
DOIs
StatePublished - Jul 1 2020

ASJC Scopus subject areas

  • Nephrology

Fingerprint Dive into the research topics of 'Branched-Chain Amino Acids Depletion during Hemodialysis Is Associated with Fatigue'. Together they form a unique fingerprint.

Cite this