BrainMap VBM: An environment for structural meta-analysis

Thomas J. Vanasse, P. Mickle Fox, Daniel S. Barron, Michaela Robertson, Simon B. Eickhoff, Jack L Lancaster, Peter T Fox

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The BrainMap database is a community resource that curates peer-reviewed, coordinate-based human neuroimaging literature. By pairing the results of neuroimaging studies with their relevant meta-data, BrainMap facilitates coordinate-based meta-analysis (CBMA) of the neuroimaging literature en masse or at the level of experimental paradigm, clinical disease, or anatomic location. Initially dedicated to the functional, task-activation literature, BrainMap is now expanding to include voxel-based morphometry (VBM) studies in a separate sector, titled: BrainMap VBM. VBM is a whole-brain, voxel-wise method that measures significant structural differences between or within groups which are reported as standardized, peak x-y-z coordinates. Here we describe BrainMap VBM, including the meta-data structure, current data volume, and automated reverse inference functions (region-to-disease profile) of this new community resource. CBMA offers a robust methodology for retaining true-positive and excluding false-positive findings across studies in the VBM literature. As with BrainMap's functional database, BrainMap VBM may be synthesized en masse or at the level of clinical disease or anatomic location. As a use-case scenario for BrainMap VBM, we illustrate a trans-diagnostic data-mining procedure wherein we explore the underlying network structure of 2,002 experiments representing over 53,000 subjects through independent components analysis (ICA). To reduce data-redundancy effects inherent to any database, we demonstrate two data-filtering approaches that proved helpful to ICA. Finally, we apply hierarchical clustering analysis (HCA) to measure network- and disease-specificity. This procedure distinguished psychiatric from neurological diseases. We invite the neuroscientific community to further exploit BrainMap VBM with other modeling approaches.

Original languageEnglish (US)
JournalHuman Brain Mapping
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Meta-Analysis
Neuroimaging
Databases
Data Mining
Cluster Analysis
Psychiatry
Brain

Keywords

  • Atrophy
  • Data-mining
  • Independent components analysis
  • Networks
  • Pattern analysis
  • Structural covariance
  • Structural magnetic resonance imaging
  • Transdiagnostic
  • Voxel-based morphometry

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

Cite this

Vanasse, T. J., Fox, P. M., Barron, D. S., Robertson, M., Eickhoff, S. B., Lancaster, J. L., & Fox, P. T. (Accepted/In press). BrainMap VBM: An environment for structural meta-analysis. Human Brain Mapping. https://doi.org/10.1002/hbm.24078

BrainMap VBM : An environment for structural meta-analysis. / Vanasse, Thomas J.; Fox, P. Mickle; Barron, Daniel S.; Robertson, Michaela; Eickhoff, Simon B.; Lancaster, Jack L; Fox, Peter T.

In: Human Brain Mapping, 01.01.2018.

Research output: Contribution to journalArticle

Vanasse, TJ, Fox, PM, Barron, DS, Robertson, M, Eickhoff, SB, Lancaster, JL & Fox, PT 2018, 'BrainMap VBM: An environment for structural meta-analysis', Human Brain Mapping. https://doi.org/10.1002/hbm.24078
Vanasse TJ, Fox PM, Barron DS, Robertson M, Eickhoff SB, Lancaster JL et al. BrainMap VBM: An environment for structural meta-analysis. Human Brain Mapping. 2018 Jan 1. https://doi.org/10.1002/hbm.24078
Vanasse, Thomas J. ; Fox, P. Mickle ; Barron, Daniel S. ; Robertson, Michaela ; Eickhoff, Simon B. ; Lancaster, Jack L ; Fox, Peter T. / BrainMap VBM : An environment for structural meta-analysis. In: Human Brain Mapping. 2018.
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