Brain norepinephrine levels in parathyroidectomized rats induced to convulse by pinealectomy

Henry H. Herrera, William W. Morgan, Russel J. Reiter

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Pargyline, a monoamine oxidase inhibitor, in the dosage of either 60 or 30 mg/kg body wt prevented seizures in parathyroidectomized rats that were induced to convulse with pinealectomy. Pargyline treatment caused elevations in telencephalic norepinephrine and dopamine concentrations and in brainstem norepinephrine levels. Convulsing rats that did not receive pargyline had depressed levels of brain norepinephrine while there was no correlation between dopamine concentrations and the propensity of the parathyroidectomized-pinalectomized rats to convulse.

Original languageEnglish (US)
Pages (from-to)595-600
Number of pages6
JournalExperimental Neurology
Volume48
Issue number3 PART 1
DOIs
StatePublished - Sep 1975

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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