Pargyline, a monoamine oxidase inhibitor, in the dosage of either 60 or 30 mg/kg body wt prevented seizures in parathyroidectomized rats that were induced to convulse with pinealectomy. Pargyline treatment caused elevations in telencephalic norepinephrine and dopamine concentrations and in brainstem norepinephrine levels. Convulsing rats that did not receive pargyline had depressed levels of brain norepinephrine while there was no correlation between dopamine concentrations and the propensity of the parathyroidectomized-pinalectomized rats to convulse.
ASJC Scopus subject areas
- Developmental Neuroscience