Brain norepinephrine levels in parathyroidectomized rats induced to convulse by pinealectomy

Henry H. Herrera; William W. Morgan; Russel J. Reiter

doi:10.1016/0014-4886(75)90016-3

Brain norepinephrine levels in parathyroidectomized rats induced to convulse by pinealectomy

Henry H. Herrera, William W. Morgan, Russel J. Reiter

Department of Cell Systems & Anatomy

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Pargyline, a monoamine oxidase inhibitor, in the dosage of either 60 or 30 mg/kg body wt prevented seizures in parathyroidectomized rats that were induced to convulse with pinealectomy. Pargyline treatment caused elevations in telencephalic norepinephrine and dopamine concentrations and in brainstem norepinephrine levels. Convulsing rats that did not receive pargyline had depressed levels of brain norepinephrine while there was no correlation between dopamine concentrations and the propensity of the parathyroidectomized-pinalectomized rats to convulse.

Original language	English (US)
Pages (from-to)	595-600
Number of pages	6
Journal	Experimental Neurology
Volume	48
Issue number	3 PART 1
DOIs	https://doi.org/10.1016/0014-4886(75)90016-3
State	Published - Sep 1975

ASJC Scopus subject areas

Neurology
Developmental Neuroscience

Access to Document

10.1016/0014-4886(75)90016-3

Cite this

@article{9e919a12b98b4bb9921bea267fb41030,

title = "Brain norepinephrine levels in parathyroidectomized rats induced to convulse by pinealectomy",

abstract = "Pargyline, a monoamine oxidase inhibitor, in the dosage of either 60 or 30 mg/kg body wt prevented seizures in parathyroidectomized rats that were induced to convulse with pinealectomy. Pargyline treatment caused elevations in telencephalic norepinephrine and dopamine concentrations and in brainstem norepinephrine levels. Convulsing rats that did not receive pargyline had depressed levels of brain norepinephrine while there was no correlation between dopamine concentrations and the propensity of the parathyroidectomized-pinalectomized rats to convulse.",

author = "Herrera, {Henry H.} and Morgan, {William W.} and Reiter, {Russel J.}",

year = "1975",

month = sep,

doi = "10.1016/0014-4886(75)90016-3",

language = "English (US)",

volume = "48",

pages = "595--600",

journal = "Experimental Neurology",

issn = "0014-4886",

publisher = "Academic Press Inc.",

number = "3 PART 1",

}

TY - JOUR

T1 - Brain norepinephrine levels in parathyroidectomized rats induced to convulse by pinealectomy

AU - Herrera, Henry H.

AU - Morgan, William W.

AU - Reiter, Russel J.

PY - 1975/9

Y1 - 1975/9

N2 - Pargyline, a monoamine oxidase inhibitor, in the dosage of either 60 or 30 mg/kg body wt prevented seizures in parathyroidectomized rats that were induced to convulse with pinealectomy. Pargyline treatment caused elevations in telencephalic norepinephrine and dopamine concentrations and in brainstem norepinephrine levels. Convulsing rats that did not receive pargyline had depressed levels of brain norepinephrine while there was no correlation between dopamine concentrations and the propensity of the parathyroidectomized-pinalectomized rats to convulse.

AB - Pargyline, a monoamine oxidase inhibitor, in the dosage of either 60 or 30 mg/kg body wt prevented seizures in parathyroidectomized rats that were induced to convulse with pinealectomy. Pargyline treatment caused elevations in telencephalic norepinephrine and dopamine concentrations and in brainstem norepinephrine levels. Convulsing rats that did not receive pargyline had depressed levels of brain norepinephrine while there was no correlation between dopamine concentrations and the propensity of the parathyroidectomized-pinalectomized rats to convulse.

UR - http://www.scopus.com/inward/record.url?scp=0016758053&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016758053&partnerID=8YFLogxK

U2 - 10.1016/0014-4886(75)90016-3

DO - 10.1016/0014-4886(75)90016-3

M3 - Article

C2 - 1175717

AN - SCOPUS:0016758053

SN - 0014-4886

VL - 48

SP - 595

EP - 600

JO - Experimental Neurology

JF - Experimental Neurology

IS - 3 PART 1

ER -

Brain norepinephrine levels in parathyroidectomized rats induced to convulse by pinealectomy

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this