Brain-muscle communication prevents muscle aging by maintaining daily physiology

Arun Kumar, Mireia Vaca-Dempere, Thomas Mortimer, Oleg Deryagin, Jacob G. Smith, Paul Petrus, Kevin B. Koronowski, Carolina M. Greco, Jessica Segalés, Eva Andrés, Vera Lukesova, Valentina M. Zinna, Patrick Simon Welz, Antonio L. Serrano, Eusebio Perdiguero, Paolo Sassone-Corsi, Salvador Aznar Benitah, Pura Muñoz-Cánoves

Research output: Contribution to journalArticlepeer-review


A molecular clock network is crucial for daily physiology and maintaining organismal health. We examined the interactions and importance of intratissue clock networks in muscle tissue maintenance. In arrhythmic mice showing premature aging, we created a basic clock module involving a central and a peripheral (muscle) clock. Reconstituting the brain-muscle clock network is sufficient to preserve fundamental daily homeostatic functions and prevent premature muscle aging. However, achieving whole muscle physiology requires contributions from other peripheral clocks. Mechanistically, the muscle peripheral clock acts as a gatekeeper, selectively suppressing detrimental signals from the central clock while integrating important muscle homeostatic functions. Our research reveals the interplay between the central and peripheral clocks in daily muscle function and underscores the impact of eating patterns on these interactions.

Original languageEnglish (US)
Pages (from-to)563-572
Number of pages10
Issue number6695
StatePublished - May 3 2024

ASJC Scopus subject areas

  • General


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