Brain-blood barrier breakdown and pro-inflammatory mediators in neonate rats submitted meningitis by Streptococcus pneumoniae

Tatiana Barichello, Glauco D. Fagundes, Jaqueline S. Generoso, Ana Paula Moreira, Caroline S. Costa, Jessiele R. Zanatta, Lutiana R. Simões, Fabricia Petronilho, Felipe Dal-Pizzol, Márcia Carvalho Vilela, Antonio Lucio Teixeira

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Neonatal meningitis is an illness characterized by inflammation of the meninges and occurring within the birth and the first 28 days of life. Invasive infection by Streptococcus pneumoniae, meningitis and sepsis, in neonate is associated with prolonged rupture of membranes; maternal colonization/illness, prematurity, high mortality and 50% of cases have some form of disability. For this purpose, we measured brain levels of TNF-α, IL-1β, IL-6, IL-10, CINC-1, oxidative damage, enzymatic defense activity and the blood-brain barrier (BBB) integrity in neonatal Wistar rats submitted to pneumococcal meningitis. The cytokines increased prior to the BBB breakdown and this breakdown occurred in the hippocampus at 18 h and in the cortex at 12 h after pneumococcal meningitis induction. The time-dependent association between the complex interactions among cytokines, chemokine may be responsible for the BBB breakdown and neonatal pneumococcal severity.

Original languageEnglish (US)
Pages (from-to)162-168
Number of pages7
JournalBrain Research
Volume1471
DOIs
StatePublished - Aug 30 2012
Externally publishedYes

Keywords

  • Blood-brain barrier
  • Chemokine
  • Cytokine
  • Meningitis
  • Streptococcus pneumoniae

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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