TY - JOUR
T1 - Brain-blood barrier breakdown and pro-inflammatory mediators in neonate rats submitted meningitis by Streptococcus pneumoniae
AU - Barichello, Tatiana
AU - Fagundes, Glauco D.
AU - Generoso, Jaqueline S.
AU - Paula Moreira, Ana
AU - Costa, Caroline S.
AU - Zanatta, Jessiele R.
AU - Simões, Lutiana R.
AU - Petronilho, Fabricia
AU - Dal-Pizzol, Felipe
AU - Carvalho Vilela, Márcia
AU - Lucio Teixeira, Antonio
PY - 2012/8/30
Y1 - 2012/8/30
N2 - Neonatal meningitis is an illness characterized by inflammation of the meninges and occurring within the birth and the first 28 days of life. Invasive infection by Streptococcus pneumoniae, meningitis and sepsis, in neonate is associated with prolonged rupture of membranes; maternal colonization/illness, prematurity, high mortality and 50% of cases have some form of disability. For this purpose, we measured brain levels of TNF-α, IL-1β, IL-6, IL-10, CINC-1, oxidative damage, enzymatic defense activity and the blood-brain barrier (BBB) integrity in neonatal Wistar rats submitted to pneumococcal meningitis. The cytokines increased prior to the BBB breakdown and this breakdown occurred in the hippocampus at 18 h and in the cortex at 12 h after pneumococcal meningitis induction. The time-dependent association between the complex interactions among cytokines, chemokine may be responsible for the BBB breakdown and neonatal pneumococcal severity.
AB - Neonatal meningitis is an illness characterized by inflammation of the meninges and occurring within the birth and the first 28 days of life. Invasive infection by Streptococcus pneumoniae, meningitis and sepsis, in neonate is associated with prolonged rupture of membranes; maternal colonization/illness, prematurity, high mortality and 50% of cases have some form of disability. For this purpose, we measured brain levels of TNF-α, IL-1β, IL-6, IL-10, CINC-1, oxidative damage, enzymatic defense activity and the blood-brain barrier (BBB) integrity in neonatal Wistar rats submitted to pneumococcal meningitis. The cytokines increased prior to the BBB breakdown and this breakdown occurred in the hippocampus at 18 h and in the cortex at 12 h after pneumococcal meningitis induction. The time-dependent association between the complex interactions among cytokines, chemokine may be responsible for the BBB breakdown and neonatal pneumococcal severity.
KW - Blood-brain barrier
KW - Chemokine
KW - Cytokine
KW - Meningitis
KW - Streptococcus pneumoniae
UR - http://www.scopus.com/inward/record.url?scp=84864700861&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864700861&partnerID=8YFLogxK
U2 - 10.1016/j.brainres.2012.06.054
DO - 10.1016/j.brainres.2012.06.054
M3 - Article
C2 - 22796596
AN - SCOPUS:84864700861
SN - 0006-8993
VL - 1471
SP - 162
EP - 168
JO - Brain Research
JF - Brain Research
ER -