Brain Arteriovenous Malformation Modeling, Pathogenesis, and Novel Therapeutic Targets

Wanqiu Chen, Eun Jung Choi, Cameron M. McDougall, Hua Su

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

Patients harboring brain arteriovenous malformation (bAVM) are at life-threatening risk of rupture and intracranial hemorrhage (ICH). The pathogenesis of bAVM has not been completely understood. Current treatment options are invasive, and ≈ 20 % of patients are not offered interventional therapy because of excessive treatment risk. There are no specific medical therapies to treat bAVMs. The lack of validated animal models has been an obstacle for testing hypotheses of bAVM pathogenesis and testing new therapies. In this review, we summarize bAVM model development and bAVM pathogenesis and potential therapeutic targets that have been identified during model development.

Original languageEnglish (US)
Pages (from-to)316-329
Number of pages14
JournalTranslational Stroke Research
Volume5
Issue number3
DOIs
StatePublished - Jun 2014

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Keywords

  • Activin-like kinase 1
  • Angiogenesis
  • Brain arteriovenous malformation
  • Conditional knockout
  • Endoglin
  • Hereditary hemorrhagic telangiectasia
  • Mouse models

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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