Brain amines and convulsions in four strains of parathyroidectomized, pinealectomized rat

R. Philo, Russel J Reiter

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The tendency for four strains of parathyroidectomized (PTx)rats to convulse after pinealectomy (Px) was observed in this experiment; telencephalic serotonin, norepinephrine, and dopamine were examined to note any correlation between amines and convulsions. The strains of rats tested were Sprague-Dawley, Wistar, Long-Evans, and ACI. Duration to onset of convulsions was shortest in the PTx + Px Long-Evans. No convulsions were noted in the PTx + Px ACI strain, but at least 70% of the animals in each of the other PTx + Px groups did convulse. The administration of calcium gluconate (70 mg/kg) intraperitoneally in saline did not alleviate convulsions in the PTx + Px Sprague-Dawley. Telencephalic serotonin was lowered in the PTx + Px Wistar while norepinephrine was depressed in the PTx + Px Long-Evans rat. Dopamine levels did not change. Previous work in the PTx + Px induced convulsion has led to the implication of norepinephrine alone, but this work indicates serotonin may be involved in some strains.

Original languageEnglish (US)
Pages (from-to)133-137
Number of pages5
JournalEpilepsia
Volume19
Issue number2
StatePublished - 1978

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Amines
Seizures
Brain
Telencephalon
Serotonin
Norepinephrine
Dopamine
Calcium Gluconate
Long Evans Rats

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Brain amines and convulsions in four strains of parathyroidectomized, pinealectomized rat. / Philo, R.; Reiter, Russel J.

In: Epilepsia, Vol. 19, No. 2, 1978, p. 133-137.

Research output: Contribution to journalArticle

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AB - The tendency for four strains of parathyroidectomized (PTx)rats to convulse after pinealectomy (Px) was observed in this experiment; telencephalic serotonin, norepinephrine, and dopamine were examined to note any correlation between amines and convulsions. The strains of rats tested were Sprague-Dawley, Wistar, Long-Evans, and ACI. Duration to onset of convulsions was shortest in the PTx + Px Long-Evans. No convulsions were noted in the PTx + Px ACI strain, but at least 70% of the animals in each of the other PTx + Px groups did convulse. The administration of calcium gluconate (70 mg/kg) intraperitoneally in saline did not alleviate convulsions in the PTx + Px Sprague-Dawley. Telencephalic serotonin was lowered in the PTx + Px Wistar while norepinephrine was depressed in the PTx + Px Long-Evans rat. Dopamine levels did not change. Previous work in the PTx + Px induced convulsion has led to the implication of norepinephrine alone, but this work indicates serotonin may be involved in some strains.

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