Bradykinin and inflammatory pain

Kenneth M Hargreaves, M. T. Roszkowski, J. Q. Swift

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The pro-inflammatory pharmacology of bradykinin has been well established. However, knowledge of the actual tissue concentrations and pharmacological manipulation of immunoreactive bradykinin in clinical and animal models of inflammation remain relatively sparse. We have developed a microdialysis method to implant probes into the inflamed tissue compartment in order to collect dialysate continuously in patients following the surgical removal of impacted third molars. Dialysate samples can be analyzed for levels of inflammatory mediators (eg., bradykinin, prostaglandins, etc) and drugs in order to determine the time-response curves for local release of substances in inflamed tissue.

Original languageEnglish (US)
Pages (from-to)65-73
Number of pages9
JournalAgents and Actions
Volume41
Issue numberSUPPL.
StatePublished - 1993
Externally publishedYes

Fingerprint

Bradykinin
Dialysis Solutions
Tissue
Pain
Pharmacology
Third Molar
Microdialysis
Prostaglandins
Animals
Animal Models
Inflammation
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Toxicology

Cite this

Hargreaves, K. M., Roszkowski, M. T., & Swift, J. Q. (1993). Bradykinin and inflammatory pain. Agents and Actions, 41(SUPPL.), 65-73.

Bradykinin and inflammatory pain. / Hargreaves, Kenneth M; Roszkowski, M. T.; Swift, J. Q.

In: Agents and Actions, Vol. 41, No. SUPPL., 1993, p. 65-73.

Research output: Contribution to journalArticle

Hargreaves, KM, Roszkowski, MT & Swift, JQ 1993, 'Bradykinin and inflammatory pain', Agents and Actions, vol. 41, no. SUPPL., pp. 65-73.
Hargreaves KM, Roszkowski MT, Swift JQ. Bradykinin and inflammatory pain. Agents and Actions. 1993;41(SUPPL.):65-73.
Hargreaves, Kenneth M ; Roszkowski, M. T. ; Swift, J. Q. / Bradykinin and inflammatory pain. In: Agents and Actions. 1993 ; Vol. 41, No. SUPPL. pp. 65-73.
@article{20b3c050e4074e21961e8c842389a61a,
title = "Bradykinin and inflammatory pain",
abstract = "The pro-inflammatory pharmacology of bradykinin has been well established. However, knowledge of the actual tissue concentrations and pharmacological manipulation of immunoreactive bradykinin in clinical and animal models of inflammation remain relatively sparse. We have developed a microdialysis method to implant probes into the inflamed tissue compartment in order to collect dialysate continuously in patients following the surgical removal of impacted third molars. Dialysate samples can be analyzed for levels of inflammatory mediators (eg., bradykinin, prostaglandins, etc) and drugs in order to determine the time-response curves for local release of substances in inflamed tissue.",
author = "Hargreaves, {Kenneth M} and Roszkowski, {M. T.} and Swift, {J. Q.}",
year = "1993",
language = "English (US)",
volume = "41",
pages = "65--73",
journal = "Inflammation Research",
issn = "1023-3830",
publisher = "Birkhauser Verlag Basel",
number = "SUPPL.",

}

TY - JOUR

T1 - Bradykinin and inflammatory pain

AU - Hargreaves, Kenneth M

AU - Roszkowski, M. T.

AU - Swift, J. Q.

PY - 1993

Y1 - 1993

N2 - The pro-inflammatory pharmacology of bradykinin has been well established. However, knowledge of the actual tissue concentrations and pharmacological manipulation of immunoreactive bradykinin in clinical and animal models of inflammation remain relatively sparse. We have developed a microdialysis method to implant probes into the inflamed tissue compartment in order to collect dialysate continuously in patients following the surgical removal of impacted third molars. Dialysate samples can be analyzed for levels of inflammatory mediators (eg., bradykinin, prostaglandins, etc) and drugs in order to determine the time-response curves for local release of substances in inflamed tissue.

AB - The pro-inflammatory pharmacology of bradykinin has been well established. However, knowledge of the actual tissue concentrations and pharmacological manipulation of immunoreactive bradykinin in clinical and animal models of inflammation remain relatively sparse. We have developed a microdialysis method to implant probes into the inflamed tissue compartment in order to collect dialysate continuously in patients following the surgical removal of impacted third molars. Dialysate samples can be analyzed for levels of inflammatory mediators (eg., bradykinin, prostaglandins, etc) and drugs in order to determine the time-response curves for local release of substances in inflamed tissue.

UR - http://www.scopus.com/inward/record.url?scp=0027155998&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027155998&partnerID=8YFLogxK

M3 - Article

C2 - 8317343

AN - SCOPUS:0027155998

VL - 41

SP - 65

EP - 73

JO - Inflammation Research

JF - Inflammation Research

SN - 1023-3830

IS - SUPPL.

ER -