Botulinum Toxin A for Treatment of Allodynia of Complex Regional Pain Syndrome: A Pilot Study

D. Safarpour, Arash Salardini, Diana Richardson, Bahman Jabbari

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Objective: To investigate the efficacy and tolerability of Botulinum toxin A (BoNT-A) in allodynia of patients with complex regional pain syndrome. Design: A total of 14 patients were studied. Eight patients were participants of a randomized, prospective, double-blind, placebo-controlled protocol. Six patients were studied prospectively in an open-label protocol. Patients were rated at baseline and at 3 weeks and 2 months after BoNT-A administration. Ratings included brief pain inventory, McGill pain questionnaire, clinical pain impact questionnaire, quantitative skin sensory test, sleep satisfaction scale, and patient global satisfaction scale. BoNT-A was injected intradermally and subcutaneously, five units/site into the allodynic area (total dose 40-200 units). Results: None of the patients with allodynia showed a significant response after treatment. The treatment was painful and poorly tolerated. Conclusion: Intrademal and subcutaneous administration of BoNT-A into the allodynic skin of the patients with complex regional pain syndrome (CRPS) failed to improve pain and was poorly tolerated. Wiley Periodicals, Inc.

Original languageEnglish (US)
Pages (from-to)1411-1414
Number of pages4
JournalPain Medicine
Issue number9
StatePublished - Sep 2010
Externally publishedYes


  • Allodynia
  • Botulinum toxin
  • Complex Regional Pain Syndrome (CRPS)
  • Reflex Sympathetic Dystrophy (RSD)

ASJC Scopus subject areas

  • General Medicine


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