Boning up on Ephrin Signaling

Gregory R. Mundy, Florent Elefteriou

Research output: Contribution to journalShort surveypeer-review

91 Scopus citations


The activities of osteoclasts, which degrade bone, and osteoblasts, which form bone, are coordinated to maintain bone homeostasis. Zhao et al. (2006) now demonstrate bidirectional signaling between these two cell populations via the transmembrane ligand ephrinB2 expressed by osteoclasts and its receptor EphB4 expressed by osteoblasts. Such bidirectional signaling limits osteoclast activity while stimulating osteoblast differentiation.

Original languageEnglish (US)
Pages (from-to)441-443
Number of pages3
Issue number3
StatePublished - Aug 4 2006
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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