Bone regeneration using emulsion freeze-dried PLGA scaffolds with median pore sizes less than 50 μm

K. Whang, D. R. Elenz, E. K. Nam, D. C. Tsai, C. H. Thomas, G. W. Nuber, M. K. Bowen, K. E. Healy

Research output: Contribution to conferencePaperpeer-review

3 Scopus citations

Abstract

Matrices of polylactic acid (PLA), polyglycolic acid (PGA), and their copolymers (PLGA) have been fabricated into scaffolds for tissue regeneration. The goals of this study are to challenge the minimum pore size requirement for bone regeneration and demonstrate that these scaffolds, with their unique microarchitecture, are capable of conducting bone regeneration in a rat calvarial critical sized defect (CSD). Mercury porosimetry and scanning electron microscopy results showed that scaffolds with different median pore sizes and high porosities are produced. Radiomorphometry on digitally processed contact radiographs revealed that the treatment groups are not significantly different from the negative controls.

Original languageEnglish (US)
Number of pages1
StatePublished - Dec 1 1996
EventProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can
Duration: May 29 1996Jun 2 1996

Other

OtherProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
CityToronto, Can
Period5/29/966/2/96

ASJC Scopus subject areas

  • Materials Science(all)

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