Bone regeneration using emulsion freeze-dried PLGA scaffolds with median pore sizes less than 50 μm

K. Whang; D. R. Elenz; E. K. Nam; D. C. Tsai; C. H. Thomas; G. W. Nuber; M. K. Bowen; K. E. Healy

Bone regeneration using emulsion freeze-dried PLGA scaffolds with median pore sizes less than 50 μm

K. Whang, D. R. Elenz, E. K. Nam, D. C. Tsai, C. H. Thomas, G. W. Nuber, M. K. Bowen, K. E. Healy

Research output: Contribution to conference › Paper › peer-review

Abstract

Matrices of polylactic acid (PLA), polyglycolic acid (PGA), and their copolymers (PLGA) have been fabricated into scaffolds for tissue regeneration. The goals of this study are to challenge the minimum pore size requirement for bone regeneration and demonstrate that these scaffolds, with their unique microarchitecture, are capable of conducting bone regeneration in a rat calvarial critical sized defect (CSD). Mercury porosimetry and scanning electron microscopy results showed that scaffolds with different median pore sizes and high porosities are produced. Radiomorphometry on digitally processed contact radiographs revealed that the treatment groups are not significantly different from the negative controls.

Original language	English (US)
Pages	292
Number of pages	1
State	Published - 1996
Externally published	Yes
Event	Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can Duration: May 29 1996 → Jun 2 1996

Other

Other	Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
City	Toronto, Can
Period	5/29/96 → 6/2/96

ASJC Scopus subject areas

General Materials Science

Cite this

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title = "Bone regeneration using emulsion freeze-dried PLGA scaffolds with median pore sizes less than 50 μm",

abstract = "Matrices of polylactic acid (PLA), polyglycolic acid (PGA), and their copolymers (PLGA) have been fabricated into scaffolds for tissue regeneration. The goals of this study are to challenge the minimum pore size requirement for bone regeneration and demonstrate that these scaffolds, with their unique microarchitecture, are capable of conducting bone regeneration in a rat calvarial critical sized defect (CSD). Mercury porosimetry and scanning electron microscopy results showed that scaffolds with different median pore sizes and high porosities are produced. Radiomorphometry on digitally processed contact radiographs revealed that the treatment groups are not significantly different from the negative controls.",

author = "K. Whang and Elenz, {D. R.} and Nam, {E. K.} and Tsai, {D. C.} and Thomas, {C. H.} and Nuber, {G. W.} and Bowen, {M. K.} and Healy, {K. E.}",

year = "1996",

language = "English (US)",

pages = "292",

note = "Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) ; Conference date: 29-05-1996 Through 02-06-1996",

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TY - CONF

T1 - Bone regeneration using emulsion freeze-dried PLGA scaffolds with median pore sizes less than 50 μm

AU - Whang, K.

AU - Elenz, D. R.

AU - Nam, E. K.

AU - Tsai, D. C.

AU - Thomas, C. H.

AU - Nuber, G. W.

AU - Bowen, M. K.

AU - Healy, K. E.

PY - 1996

Y1 - 1996

N2 - Matrices of polylactic acid (PLA), polyglycolic acid (PGA), and their copolymers (PLGA) have been fabricated into scaffolds for tissue regeneration. The goals of this study are to challenge the minimum pore size requirement for bone regeneration and demonstrate that these scaffolds, with their unique microarchitecture, are capable of conducting bone regeneration in a rat calvarial critical sized defect (CSD). Mercury porosimetry and scanning electron microscopy results showed that scaffolds with different median pore sizes and high porosities are produced. Radiomorphometry on digitally processed contact radiographs revealed that the treatment groups are not significantly different from the negative controls.

AB - Matrices of polylactic acid (PLA), polyglycolic acid (PGA), and their copolymers (PLGA) have been fabricated into scaffolds for tissue regeneration. The goals of this study are to challenge the minimum pore size requirement for bone regeneration and demonstrate that these scaffolds, with their unique microarchitecture, are capable of conducting bone regeneration in a rat calvarial critical sized defect (CSD). Mercury porosimetry and scanning electron microscopy results showed that scaffolds with different median pore sizes and high porosities are produced. Radiomorphometry on digitally processed contact radiographs revealed that the treatment groups are not significantly different from the negative controls.

UR - http://www.scopus.com/inward/record.url?scp=0030398297&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030398297&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:0030398297

SP - 292

T2 - Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)

Y2 - 29 May 1996 through 2 June 1996

ER -

Bone regeneration using emulsion freeze-dried PLGA scaffolds with median pore sizes less than 50 μm

Abstract

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ASJC Scopus subject areas

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