TY - JOUR
T1 - Bone mineral density and the risk of alzheimer disease
AU - Tan, Zaldy Sy
AU - Seshadri, Sudha
AU - Beiser, Alexa
AU - Zhang, Yuqing
AU - Felson, David
AU - Hannan, Marian T.
AU - Au, Rhoda
AU - Wolf, Philip A.
AU - Kiel, Douglas P.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2005/1
Y1 - 2005/1
N2 - Background: Some, but not all, studies have suggested that estrogen replacement therapy has a beneficial effect on cognition in postmenopausal women. Bone mineral density (BMD) is a potential surrogate marker for cumulative estrogen exposure and has been associated with cognitive performance and risk of cognitive deterioration. Objective: To examine whether low BMD in elderly individuals is associated with an increased risk of developing Alzheimer disease (AD). Design, Setting, and Participants: Community-based prospective cohort study of 987 subjects (610 women) who were cognitively intact and had baseline BMD measured at the femoral neck, the trochanter, and the radial shaft between 1988 and 1989. Main Outcome Measures: Incidence of AD and all-cause dementia during an 8-year follow-up period. Results: Women in the lowest quartile of femoral neck BMD had more than twice the incidence of AD (hazard ratio, 2.04; 95% confidence interval, 1.11-3.75) and all-cause dementia (hazard ratio, 2.01; 95% confidence interval, 1.16-3.49) compared with those in higher quartiles after adjusting for age, sex, apolipoprotein E ε4, baseline homocysteine level, education, estrogen use, smoking, and stroke. A similar but statistically nonsignificant relationship was observed between BMD of the femoral trochanter and AD, while no such relationship was seen between radial BMD and AD or all-cause dementia. In men, there was a trend toward an inverse relationship between BMD and the risk of AD, but the relationship was not statistically significant at any of the 3 sites. Conclusions: Low femoral neck BMD was associated with approximately 2 times the risk of AD and all-cause dementia in women but not men, suggesting the possibility that cumulative estrogen exposure may influence the risk of developing AD. Additional studies are needed to confirm this correlation.
AB - Background: Some, but not all, studies have suggested that estrogen replacement therapy has a beneficial effect on cognition in postmenopausal women. Bone mineral density (BMD) is a potential surrogate marker for cumulative estrogen exposure and has been associated with cognitive performance and risk of cognitive deterioration. Objective: To examine whether low BMD in elderly individuals is associated with an increased risk of developing Alzheimer disease (AD). Design, Setting, and Participants: Community-based prospective cohort study of 987 subjects (610 women) who were cognitively intact and had baseline BMD measured at the femoral neck, the trochanter, and the radial shaft between 1988 and 1989. Main Outcome Measures: Incidence of AD and all-cause dementia during an 8-year follow-up period. Results: Women in the lowest quartile of femoral neck BMD had more than twice the incidence of AD (hazard ratio, 2.04; 95% confidence interval, 1.11-3.75) and all-cause dementia (hazard ratio, 2.01; 95% confidence interval, 1.16-3.49) compared with those in higher quartiles after adjusting for age, sex, apolipoprotein E ε4, baseline homocysteine level, education, estrogen use, smoking, and stroke. A similar but statistically nonsignificant relationship was observed between BMD of the femoral trochanter and AD, while no such relationship was seen between radial BMD and AD or all-cause dementia. In men, there was a trend toward an inverse relationship between BMD and the risk of AD, but the relationship was not statistically significant at any of the 3 sites. Conclusions: Low femoral neck BMD was associated with approximately 2 times the risk of AD and all-cause dementia in women but not men, suggesting the possibility that cumulative estrogen exposure may influence the risk of developing AD. Additional studies are needed to confirm this correlation.
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U2 - 10.1001/archneur.62.1.107
DO - 10.1001/archneur.62.1.107
M3 - Article
C2 - 15642856
AN - SCOPUS:12144277271
VL - 62
SP - 107
EP - 111
JO - Archives of Neurology
JF - Archives of Neurology
SN - 0003-9942
IS - 1
ER -