Bone Bioengineering: Scaffolds, Growth Factors, and Stem Cells

Christopher S.D. Lee, Christopher D. Hermann, Rolando Gittens, Rene Olivares-Navarrete, Zvi Schwartz, Barbara D. Boyan

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

The combination of scaffolds, growth factors, and stem cells is currently being investigated in preclinical and clinical studies. This chapter describes the various components, different enabling technologies to enhance these components, and their application in craniofacial bone repair. Scaffolds with high toughness levels, or the ability to absorb large amounts of energy at failure are also commonly used for bone bioengineering. The combination of scaffolds, growth factors, and stem cells alone is often not enough to effectively bioengineer craniofacial bone. This approach allows scaffolds to respond better to resident stem cells and MMPs naturally secreted during bone regeneration.

Original languageEnglish (US)
Title of host publicationStem Cells in Craniofacial Development and Regeneration
PublisherJohn Wiley and Sons
Pages339-366
Number of pages28
ISBN (Print)9781118279236
DOIs
StatePublished - Mar 26 2013

Keywords

  • Bone bioengineering
  • Craniofacial bone
  • Growth factors
  • Scaffolds
  • Stem cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Lee, C. S. D., Hermann, C. D., Gittens, R., Olivares-Navarrete, R., Schwartz, Z., & Boyan, B. D. (2013). Bone Bioengineering: Scaffolds, Growth Factors, and Stem Cells. In Stem Cells in Craniofacial Development and Regeneration (pp. 339-366). John Wiley and Sons. https://doi.org/10.1002/9781118498026.ch19