Abstract
The combination of scaffolds, growth factors, and stem cells is currently being investigated in preclinical and clinical studies. This chapter describes the various components, different enabling technologies to enhance these components, and their application in craniofacial bone repair. Scaffolds with high toughness levels, or the ability to absorb large amounts of energy at failure are also commonly used for bone bioengineering. The combination of scaffolds, growth factors, and stem cells alone is often not enough to effectively bioengineer craniofacial bone. This approach allows scaffolds to respond better to resident stem cells and MMPs naturally secreted during bone regeneration.
Original language | English (US) |
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Title of host publication | Stem Cells in Craniofacial Development and Regeneration |
Publisher | John Wiley and Sons |
Pages | 339-366 |
Number of pages | 28 |
ISBN (Print) | 9781118279236 |
DOIs | |
State | Published - Mar 26 2013 |
Keywords
- Bone bioengineering
- Craniofacial bone
- Growth factors
- Scaffolds
- Stem cells
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)