Abstract
The combination of scaffolds, growth factors, and stem cells is currently being investigated in preclinical and clinical studies. This chapter describes the various components, different enabling technologies to enhance these components, and their application in craniofacial bone repair. Scaffolds with high toughness levels, or the ability to absorb large amounts of energy at failure are also commonly used for bone bioengineering. The combination of scaffolds, growth factors, and stem cells alone is often not enough to effectively bioengineer craniofacial bone. This approach allows scaffolds to respond better to resident stem cells and MMPs naturally secreted during bone regeneration.
| Original language | English (US) |
|---|---|
| Title of host publication | Stem Cells in Craniofacial Development and Regeneration |
| Publisher | John Wiley and Sons |
| Pages | 339-366 |
| Number of pages | 28 |
| ISBN (Print) | 9781118279236 |
| DOIs | |
| State | Published - Mar 26 2013 |
| Externally published | Yes |
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Keywords
- Bone bioengineering
- Craniofacial bone
- Growth factors
- Scaffolds
- Stem cells
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Bone Bioengineering : Scaffolds, Growth Factors, and Stem Cells. / Lee, Christopher S D; Hermann, Christopher D.; Gittens, Rolando; Olivares-Navarrete, Rene; Schwartz, Zvi; Boyan, Barbara D.
Stem Cells in Craniofacial Development and Regeneration. John Wiley and Sons, 2013. p. 339-366.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Bone Bioengineering
T2 - Scaffolds, Growth Factors, and Stem Cells
AU - Lee, Christopher S D
AU - Hermann, Christopher D.
AU - Gittens, Rolando
AU - Olivares-Navarrete, Rene
AU - Schwartz, Zvi
AU - Boyan, Barbara D.
PY - 2013/3/26
Y1 - 2013/3/26
N2 - The combination of scaffolds, growth factors, and stem cells is currently being investigated in preclinical and clinical studies. This chapter describes the various components, different enabling technologies to enhance these components, and their application in craniofacial bone repair. Scaffolds with high toughness levels, or the ability to absorb large amounts of energy at failure are also commonly used for bone bioengineering. The combination of scaffolds, growth factors, and stem cells alone is often not enough to effectively bioengineer craniofacial bone. This approach allows scaffolds to respond better to resident stem cells and MMPs naturally secreted during bone regeneration.
AB - The combination of scaffolds, growth factors, and stem cells is currently being investigated in preclinical and clinical studies. This chapter describes the various components, different enabling technologies to enhance these components, and their application in craniofacial bone repair. Scaffolds with high toughness levels, or the ability to absorb large amounts of energy at failure are also commonly used for bone bioengineering. The combination of scaffolds, growth factors, and stem cells alone is often not enough to effectively bioengineer craniofacial bone. This approach allows scaffolds to respond better to resident stem cells and MMPs naturally secreted during bone regeneration.
KW - Bone bioengineering
KW - Craniofacial bone
KW - Growth factors
KW - Scaffolds
KW - Stem cells
UR - http://www.scopus.com/inward/record.url?scp=84887245728&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84887245728&partnerID=8YFLogxK
U2 - 10.1002/9781118498026.ch19
DO - 10.1002/9781118498026.ch19
M3 - Chapter
SN - 9781118279236
SP - 339
EP - 366
BT - Stem Cells in Craniofacial Development and Regeneration
PB - John Wiley and Sons
ER -