Bone Bioengineering: Scaffolds, Growth Factors, and Stem Cells

Christopher S.D. Lee; Christopher D. Hermann; Rolando Gittens; Rene Olivares-Navarrete; Zvi Schwartz; Barbara D. Boyan

doi:10.1002/9781118498026.ch19

Bone Bioengineering: Scaffolds, Growth Factors, and Stem Cells

Christopher S.D. Lee, Christopher D. Hermann, Rolando Gittens, Rene Olivares-Navarrete, Zvi Schwartz, Barbara D. Boyan

Department of Periodontics

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

The combination of scaffolds, growth factors, and stem cells is currently being investigated in preclinical and clinical studies. This chapter describes the various components, different enabling technologies to enhance these components, and their application in craniofacial bone repair. Scaffolds with high toughness levels, or the ability to absorb large amounts of energy at failure are also commonly used for bone bioengineering. The combination of scaffolds, growth factors, and stem cells alone is often not enough to effectively bioengineer craniofacial bone. This approach allows scaffolds to respond better to resident stem cells and MMPs naturally secreted during bone regeneration.

Original language	English (US)
Title of host publication	Stem Cells in Craniofacial Development and Regeneration
Publisher	John Wiley and Sons
Pages	339-366
Number of pages	28
ISBN (Print)	9781118279236
DOIs	https://doi.org/10.1002/9781118498026.ch19
State	Published - Mar 26 2013

Keywords

Bone bioengineering
Craniofacial bone
Growth factors
Scaffolds
Stem cells

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1002/9781118498026.ch19

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abstract = "The combination of scaffolds, growth factors, and stem cells is currently being investigated in preclinical and clinical studies. This chapter describes the various components, different enabling technologies to enhance these components, and their application in craniofacial bone repair. Scaffolds with high toughness levels, or the ability to absorb large amounts of energy at failure are also commonly used for bone bioengineering. The combination of scaffolds, growth factors, and stem cells alone is often not enough to effectively bioengineer craniofacial bone. This approach allows scaffolds to respond better to resident stem cells and MMPs naturally secreted during bone regeneration.",

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AU - Hermann, Christopher D.

AU - Gittens, Rolando

AU - Olivares-Navarrete, Rene

AU - Schwartz, Zvi

AU - Boyan, Barbara D.

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KW - Growth factors

KW - Scaffolds

KW - Stem cells

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Bone Bioengineering: Scaffolds, Growth Factors, and Stem Cells

Abstract

Keywords

ASJC Scopus subject areas

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