Bone ALP and OC reference standards in adult baboons (Papio hamadryas) by sex and age

Lorena M. Havill, L. G. Hale, D. E. Newman, S. M. Witte, M. C. Mahaney

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: Serum bone-specific alkaline phosphatase (bone ALP) and intact osteocalcin (OC) are markers of bone formation of interest becau of easy measurability and potential utility as identifiers of those at risk for fractures associated with bone metabolism disorders. The baboon (Papio hamadryas) exhibits extensive biological similarities to humans making it particularly well suited to studies of bone maintenance and turnover. Methods: We measured serum bone ALP and OC in 591 baboons. Results: We report significant sex and age effects and present reference ranges and percentile distributions for these markers. Conclusions: This study is the first to characterize normal variation in bone ALP and OC levels in baboons and to assess the age and sex effects on this variation. The results provide much-needed reference standards to allow researchers to evaluate the status of their animals in cross-sectional studies and assess the meaning of changes in bone ALP and OC levels in longitudinal studies.

Original languageEnglish (US)
Pages (from-to)97-105
Number of pages9
JournalJournal of Medical Primatology
Volume35
Issue number2
DOIs
StatePublished - Apr 2006
Externally publishedYes

Fingerprint

Papio hamadryas
osteocalcin
Papio
reference standards
Osteocalcin
bones
Alkaline Phosphatase
alkaline phosphatase
Bone and Bones
gender
bone metabolism
Bone Remodeling
longitudinal studies
bone formation
Serum
Osteogenesis
cross-sectional studies
Longitudinal Studies
Reference Values
Cross-Sectional Studies

Keywords

  • Baboon
  • Bone biomarkers
  • Bone Gla protein
  • Bone-specific alkaline phosphatase
  • Non-humanprimate
  • Osteoporosis risk factor

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Bone ALP and OC reference standards in adult baboons (Papio hamadryas) by sex and age. / Havill, Lorena M.; Hale, L. G.; Newman, D. E.; Witte, S. M.; Mahaney, M. C.

In: Journal of Medical Primatology, Vol. 35, No. 2, 04.2006, p. 97-105.

Research output: Contribution to journalArticle

Havill, Lorena M. ; Hale, L. G. ; Newman, D. E. ; Witte, S. M. ; Mahaney, M. C. / Bone ALP and OC reference standards in adult baboons (Papio hamadryas) by sex and age. In: Journal of Medical Primatology. 2006 ; Vol. 35, No. 2. pp. 97-105.
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AU - Mahaney, M. C.

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