Bone ALP and OC reference standards in adult baboons (Papio hamadryas) by sex and age

Lorena M. Havill; L. G. Hale; D. E. Newman; S. M. Witte; M. C. Mahaney

doi:10.1111/j.1600-0684.2006.00150.x

Bone ALP and OC reference standards in adult baboons (Papio hamadryas) by sex and age

Lorena M. Havill, L. G. Hale, D. E. Newman, S. M. Witte, M. C. Mahaney

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Background: Serum bone-specific alkaline phosphatase (bone ALP) and intact osteocalcin (OC) are markers of bone formation of interest becau of easy measurability and potential utility as identifiers of those at risk for fractures associated with bone metabolism disorders. The baboon (Papio hamadryas) exhibits extensive biological similarities to humans making it particularly well suited to studies of bone maintenance and turnover. Methods: We measured serum bone ALP and OC in 591 baboons. Results: We report significant sex and age effects and present reference ranges and percentile distributions for these markers. Conclusions: This study is the first to characterize normal variation in bone ALP and OC levels in baboons and to assess the age and sex effects on this variation. The results provide much-needed reference standards to allow researchers to evaluate the status of their animals in cross-sectional studies and assess the meaning of changes in bone ALP and OC levels in longitudinal studies.

Original language	English (US)
Pages (from-to)	97-105
Number of pages	9
Journal	Journal of medical primatology
Volume	35
Issue number	2
DOIs	https://doi.org/10.1111/j.1600-0684.2006.00150.x
State	Published - Apr 2006

Keywords

Baboon
Bone Gla protein
Bone biomarkers
Bone-specific alkaline phosphatase
Non-humanprimate
Osteoporosis risk factor

ASJC Scopus subject areas

Animal Science and Zoology
veterinary(all)

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10.1111/j.1600-0684.2006.00150.x

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title = "Bone ALP and OC reference standards in adult baboons (Papio hamadryas) by sex and age",

abstract = "Background: Serum bone-specific alkaline phosphatase (bone ALP) and intact osteocalcin (OC) are markers of bone formation of interest becau of easy measurability and potential utility as identifiers of those at risk for fractures associated with bone metabolism disorders. The baboon (Papio hamadryas) exhibits extensive biological similarities to humans making it particularly well suited to studies of bone maintenance and turnover. Methods: We measured serum bone ALP and OC in 591 baboons. Results: We report significant sex and age effects and present reference ranges and percentile distributions for these markers. Conclusions: This study is the first to characterize normal variation in bone ALP and OC levels in baboons and to assess the age and sex effects on this variation. The results provide much-needed reference standards to allow researchers to evaluate the status of their animals in cross-sectional studies and assess the meaning of changes in bone ALP and OC levels in longitudinal studies.",

keywords = "Baboon, Bone Gla protein, Bone biomarkers, Bone-specific alkaline phosphatase, Non-humanprimate, Osteoporosis risk factor",

author = "Havill, {Lorena M.} and Hale, {L. G.} and Newman, {D. E.} and Witte, {S. M.} and Mahaney, {M. C.}",

year = "2006",

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doi = "10.1111/j.1600-0684.2006.00150.x",

language = "English (US)",

volume = "35",

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journal = "Journal of Medical Primatology",

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T1 - Bone ALP and OC reference standards in adult baboons (Papio hamadryas) by sex and age

AU - Havill, Lorena M.

AU - Hale, L. G.

AU - Newman, D. E.

AU - Witte, S. M.

AU - Mahaney, M. C.

PY - 2006/4

Y1 - 2006/4

N2 - Background: Serum bone-specific alkaline phosphatase (bone ALP) and intact osteocalcin (OC) are markers of bone formation of interest becau of easy measurability and potential utility as identifiers of those at risk for fractures associated with bone metabolism disorders. The baboon (Papio hamadryas) exhibits extensive biological similarities to humans making it particularly well suited to studies of bone maintenance and turnover. Methods: We measured serum bone ALP and OC in 591 baboons. Results: We report significant sex and age effects and present reference ranges and percentile distributions for these markers. Conclusions: This study is the first to characterize normal variation in bone ALP and OC levels in baboons and to assess the age and sex effects on this variation. The results provide much-needed reference standards to allow researchers to evaluate the status of their animals in cross-sectional studies and assess the meaning of changes in bone ALP and OC levels in longitudinal studies.

AB - Background: Serum bone-specific alkaline phosphatase (bone ALP) and intact osteocalcin (OC) are markers of bone formation of interest becau of easy measurability and potential utility as identifiers of those at risk for fractures associated with bone metabolism disorders. The baboon (Papio hamadryas) exhibits extensive biological similarities to humans making it particularly well suited to studies of bone maintenance and turnover. Methods: We measured serum bone ALP and OC in 591 baboons. Results: We report significant sex and age effects and present reference ranges and percentile distributions for these markers. Conclusions: This study is the first to characterize normal variation in bone ALP and OC levels in baboons and to assess the age and sex effects on this variation. The results provide much-needed reference standards to allow researchers to evaluate the status of their animals in cross-sectional studies and assess the meaning of changes in bone ALP and OC levels in longitudinal studies.

KW - Baboon

KW - Bone Gla protein

KW - Bone biomarkers

KW - Bone-specific alkaline phosphatase

KW - Non-humanprimate

KW - Osteoporosis risk factor

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Bone ALP and OC reference standards in adult baboons (Papio hamadryas) by sex and age

Abstract

Keywords

ASJC Scopus subject areas

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