TY - JOUR
T1 - Body water estimates in neonatal polycythemia
AU - Thornton, Cynthia J.
AU - Shannon, Donna L.
AU - Hunter, Mary Ann
AU - Ramamurthy, Rajam S.
AU - Brans, Yves W.
N1 - Funding Information:
From the Perinatal Research Laboratory, Departments of Pediatrics and of Obstetrics and Gynecology, University of Texas Health Science Center. Supported in part by Biomedical Research Grant RR05654 of the National Institutes of Health. Reprint address: Yves W. Brans, M.D., Department of Pediatrics, University of Texas Health Science Center, 7703 Floyd Curl Dr., San Antonio, TX 78284.
PY - 1983/1
Y1 - 1983/1
N2 - To determine whether neonatal polycythemia and its treatment by partial exchange transfusion affect body water estimates, 10 normocythemic and eight polycythemic neonates were studied within 12 hours of birth. Total body water, extracellular water, and plasma volume were estimated immediately prior to and following exchange. Intracellular and interstitial water contents were calculated. There were no significant differences between normocythemic and preexchange polycythemic neonates in mean total body water, extracellular water, interstitial water, and intracellular water contents. In the polycythemic group, exchange did not affect mean total body water, but was associated with decreases in mean extracellular water and mean interstitial water and an increase in mean intracellular water. Mean transcapillary escape rate of T-1824 was not affected by exchange but was quite rapid both before (35±SE 3%/hr) and after the procedure (30±4.9%/hr). These data suggest that moderate polycythemia in normal term neonates does not affect total and extravascular body water estimates, but that a fluid shift from the extracellular to the intracellular space may accompany the exchange procedure.
AB - To determine whether neonatal polycythemia and its treatment by partial exchange transfusion affect body water estimates, 10 normocythemic and eight polycythemic neonates were studied within 12 hours of birth. Total body water, extracellular water, and plasma volume were estimated immediately prior to and following exchange. Intracellular and interstitial water contents were calculated. There were no significant differences between normocythemic and preexchange polycythemic neonates in mean total body water, extracellular water, interstitial water, and intracellular water contents. In the polycythemic group, exchange did not affect mean total body water, but was associated with decreases in mean extracellular water and mean interstitial water and an increase in mean intracellular water. Mean transcapillary escape rate of T-1824 was not affected by exchange but was quite rapid both before (35±SE 3%/hr) and after the procedure (30±4.9%/hr). These data suggest that moderate polycythemia in normal term neonates does not affect total and extravascular body water estimates, but that a fluid shift from the extracellular to the intracellular space may accompany the exchange procedure.
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U2 - 10.1016/S0022-3476(83)80304-7
DO - 10.1016/S0022-3476(83)80304-7
M3 - Article
C2 - 6848708
AN - SCOPUS:0020686434
VL - 102
SP - 113
EP - 117
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 1
ER -