Body composition and adipokines plasma levels in patients with myasthenia gravis treated with high cumulative glucocorticoid dose

Nayara Felicidade Tomaz Braz, Natalia Pessoa Rocha, Érica Leandro Marciano Vieira, Rodrigo Santiago Gomez, Adriana Maria Kakehasi, Antonio Lucio Teixeira

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

This study aimed to evaluate changes in body composition, i.e. overweight, obesity, fat accumulation and low lean body mass and plasma levels of adipokines in patients with MG. The study enrolled 80 patients with MG, and 62 controls. Body fat mass and body lean mass was analyzed by dual-energy X-ray absorptiometry technique (DXA). Plasma levels of leptin were analyzed by Luminex® and adiponectin and resistin were analyzed by ELISA. The mean age of patients with MG was 41.9 years, with 13.5 years of length of illness, and mean cumulative dose of glucocorticoids 38,123 mg. Our results showed that the frequency of obesity is higher in MG patients than in controls, and patients with MG presented higher body fat mass, android body adiposity and total body fat than controls. MG patients presented lower levels of resistin and higher levels of leptin in comparison with controls. There were no differences in the plasma levels of adiponectin. Higher total body fat and lower body lean mass were associated with increased severity of MG symptoms. This result points to the relevance of estimation of body composition in planning long-term care of MG patients.

Original languageEnglish (US)
Pages (from-to)169-175
Number of pages7
JournalJournal of the Neurological Sciences
Volume381
DOIs
StatePublished - Oct 15 2017
Externally publishedYes

Keywords

  • Adipokines
  • Body composition
  • Dual-energy X-ray absorptiometry
  • Myasthenia gravis
  • Obesity

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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