Blood substitutes

S. M. Cohn

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Specific blood substitutes (hemoglobin-based) have passed safety studies and are now undergoing efficacy evaluation. These solutions have a long shelf life, do not require typing and cross-matching, are free of viral or bacterial contamination, appear to lack the immunosuppressive effects of blood, and have a much lower viscosity than blood. One third of the 10 million units of blood transfused in the United States each year are utilized in critically ill patients in an emergency setting. A safe substitute for blood should have a substantial impact on the way that we resuscitate critically ill patients. Also, the potential exists for use of these solutions as oxygen-therapeutic agents in increasing oxygen delivery to patients with ischemia (i.e., stroke, myocardial infarction, organ dysfunction).

Original languageEnglish (US)
Pages (from-to)54-60
Number of pages7
JournalNew Horizons: Science and Practice of Acute Medicine
Issue number1
StatePublished - Jan 1 1999


  • Acute anemia
  • Blood substitutes
  • Blood transfusion
  • Hemoglobin

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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