TY - JOUR
T1 - Blood pressure of rats lowered by sulfur dioxide and its derivatives
AU - Meng, Ziqiang
AU - Geng, Hong
AU - Bai, Juli
AU - Yan, Guanghai
N1 - Funding Information:
Received 6 December 2002; sent for revision 5 January 2003; accepted 13 February 2003. This study was supported by grant 30070647 from the National Natural Science Foundation of China and by a grant from the National Natural Science Foundation of Shanxi Province. Address correspondence to Prof. Dr. Ziqiang Meng, Institute of Environmental Medicine and Toxicology, Shanxi University, Taiyuan 030006, P.R. China. E-mail: zqmeng@sxu.edu.cn
PY - 2003/8
Y1 - 2003/8
N2 - This study was designed to investigate effects of sulfur dioxide (SO 2) and its derivatives (bisulfite and sulfite) on the rat blood pressure. The blood pressures of male Wistar rats exposed to SO2 and its derivatives at various doses were measured. Findings were that: (1) with acute-one time exposure to SO2 for 6 h, the rat blood pressures were lowered in contrast to their controls and their background levels in a dose-dependent manner. (2) There were both a dose-response relationship and a time-response relationship between subchronic SO2 exposure and the rat blood pressure. For SO2 exposure at 10 ppm, first the blood pressures decreased significantly with exposure days in contrast to their controls and their background levels, and then these decreases became not significant, suggesting an adaption mechanism might be induced. However, SO 2 exposures at 40 ppm caused significant decreases of the blood pressures during the whole experiment, and no adaptation process was found. (3) SO2 derivatives (bisulfite and sulfite) also caused the decreases of rat blood pressures in a dose-dependent manner. There are two conclusions: (1) Short-time, even acute one-time, exposure to SO2 of its derivatives may cause a decrease of blood pressure of the animals in both dose-dependent and time-dependent manners. (2) SO2 is a systemic toxic agent, not only to the respiratory system. SO2 can cause at least functional damage to the cardiovascular system.
AB - This study was designed to investigate effects of sulfur dioxide (SO 2) and its derivatives (bisulfite and sulfite) on the rat blood pressure. The blood pressures of male Wistar rats exposed to SO2 and its derivatives at various doses were measured. Findings were that: (1) with acute-one time exposure to SO2 for 6 h, the rat blood pressures were lowered in contrast to their controls and their background levels in a dose-dependent manner. (2) There were both a dose-response relationship and a time-response relationship between subchronic SO2 exposure and the rat blood pressure. For SO2 exposure at 10 ppm, first the blood pressures decreased significantly with exposure days in contrast to their controls and their background levels, and then these decreases became not significant, suggesting an adaption mechanism might be induced. However, SO 2 exposures at 40 ppm caused significant decreases of the blood pressures during the whole experiment, and no adaptation process was found. (3) SO2 derivatives (bisulfite and sulfite) also caused the decreases of rat blood pressures in a dose-dependent manner. There are two conclusions: (1) Short-time, even acute one-time, exposure to SO2 of its derivatives may cause a decrease of blood pressure of the animals in both dose-dependent and time-dependent manners. (2) SO2 is a systemic toxic agent, not only to the respiratory system. SO2 can cause at least functional damage to the cardiovascular system.
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U2 - 10.1080/08958370390215785
DO - 10.1080/08958370390215785
M3 - Article
C2 - 12872180
AN - SCOPUS:0042358819
SN - 0895-8378
VL - 15
SP - 951
EP - 959
JO - Inhalation Toxicology
JF - Inhalation Toxicology
IS - 9
ER -