Blood longitudinal (T1) and transverse (T2) relaxation time constants at 11.7 Tesla.

Ai Ling Lin, Qin Qin, Xia Zhao, Timothy Q. Duong

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The goal of the study was to determine blood T(1) and T(2) values as functions of oxygen saturation (Y), temperature (Temp) and hematocrit (Hct) at an ultrahigh MR field (11.7 T) and explore their impacts on physiological measurements, including cerebral blood flow (CBF), blood volume (CBV) and oxygenation determination. T(1) and T(2) were simultaneously measured. Temperature was adjusted from 25 to 40°C to determine Temp dependence; Hct of 0.17-0.51 to evaluate Hct dependence at 25 and 37°C; and Y of 40-100% to evaluate Y dependence at 25 and 37°C. Comparisons were made with published data obtained at different magnetic field strengths (B(0)). T(1) was positively correlated with Temp, independent of Y, and negatively correlated with Hct. T(2) was negatively correlated with Temp and Hct, but positively correlated with Y, in a non-linear fashion. T(1) increased linearly with B(0), whereas T(2) decreased exponentially with B(0). This study reported blood T(1) and T(2) measurements at 11.7 T for the first time. These blood relaxation data could have implications in numerous functional and physiological MRI studies at 11.7 T.

Original languageEnglish (US)
Pages (from-to)245-249
Number of pages5
JournalMagma (New York, N.Y.)
Volume25
Issue number3
DOIs
StatePublished - Jun 2012

Fingerprint

Hematocrit
Temperature
Cerebrovascular Circulation
Blood Volume Determination
Magnetic Fields
Magnetic Resonance Imaging
Oxygen

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Blood longitudinal (T1) and transverse (T2) relaxation time constants at 11.7 Tesla. / Lin, Ai Ling; Qin, Qin; Zhao, Xia; Duong, Timothy Q.

In: Magma (New York, N.Y.), Vol. 25, No. 3, 06.2012, p. 245-249.

Research output: Contribution to journalArticle

Lin, Ai Ling ; Qin, Qin ; Zhao, Xia ; Duong, Timothy Q. / Blood longitudinal (T1) and transverse (T2) relaxation time constants at 11.7 Tesla. In: Magma (New York, N.Y.). 2012 ; Vol. 25, No. 3. pp. 245-249.
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