Blood group antigens, Lewis(x) and Lewis(y) in the diagnostic discrimination of malignant mesothelioma versus adenocarcinoma

D. Jordon, J. Jagirdar, M. Kaneko

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42 Scopus citations

Abstract

Despite major advances in the differential diagnosis of mesotheliomas versus adenocarcinomas, a certain percentage defy diagnosis. Several markers such as keratin, carcinoembryonic antigen, Leu-M1, milk fat globulin, and antibody against tumor-associated glycoprotein Tag-72 (B72.3) have been used to distinguish them. In this study, blood group antigens, namely Lewis(x) and Lewis(y), known to be expressed in a number os adenocarcinomas of diverse origin were used in the differential diagnosis of 30 samples from 18 mesotheliomas and 18 primary lung adenocarcinomas. Adenocarcinomas showed strong diffuse homogeneous staining, membranous staining, or both for Lewis(y) in 100% of cases irrespective of differentiation. Lewis(x) was expressed in 78% of adenocarcinomas with a wide variation in distribution of staining. Mesotheliomas did not show the diffuse homogeneous staining pattern but showed a markedly distinctive granular staining in the cytoplasm of rare cells in 23% of Lewis(y) and 20% of Lewis(x) cases, which was interpreted as negative. In conclusion, Lewis(y) is a sensitive marker for adenocarcinomas in that it stains 100% of cases and is a specific marker in the differential diagnosis of mesotheliomas and adenocarcinomas.

Original languageEnglish (US)
Pages (from-to)931-937
Number of pages7
JournalAmerican Journal of Pathology
Volume135
Issue number5
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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