Bizarre epithelioid lipoleiomyoma of the uterus

John J. Brooks, Gregg B. Wells, I. Tien Yeh, Virginia A. Li Volsi

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Lipoleiomyomas of the uterus are extremely rare. All previous examples have been composed of two mature elements: bland spindled smooth muscle cells and bland adipose tissue. We report a unique case of a uterine tumor containing four morphologic cell types: mature spindled smooth muscle cells with and without nuclear atypia, epithelioid smooth muscle cells with and without nuclear atypia, mature adipose tissue, and immature fat cells and lipoblasts with marked nuclear atypia. No mitotic features were noted despite an extensive search. Description of this extremely unusual variant, believed to be the first reported of its kind, should enable pathologists to avoid a diagnosis of malignancy. Further, histologic evidence of a direct metaplasic origin of the adipose differentiation could be found and was supported by immunohistochemical findings.

Original languageEnglish (US)
Pages (from-to)144-149
Number of pages6
JournalInternational Journal of Gynecological Pathology
Issue number2
StatePublished - Apr 1992
Externally publishedYes


  • Adiose tissue
  • Lipoleiomyoma
  • Nuclear atypia
  • Smooth muscle cells

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynecology

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