Bivariate linkage between acylation-stimulating protein and BMI and high-density lipoproteins

Lisa J. Martin, Katherine Cianflone, Robert Zakarian, Gauri Nagrani, Laura Almasy, David L. Rainwater, Shelley Cole, James E. Hixson, Jean W. MacCluer, John Blangero, Anthony G. Comuzzie

    Research output: Contribution to journalArticlepeer-review

    20 Scopus citations

    Abstract

    Objective: Given the importance of visceral adiposity in the metabolic syndrome, whether levels of adipokines have shared genetic effects (pleiotropy) with aspects of the metabolic syndrome should be addressed. Acylation- stimulating protein (ASP), an adipose-derived protein, influences lipid metabolism, obesity, and glucose use. Therefore, our objective was to examine the genetic regulation of ASP and associated pleiotropic effects. Research Methods and Procedures: We assayed serum ASP levels in 435 Mexican Americans participating in the San Antonio Family Heart Study and performed univariate and bivariate variance components analysis. Results: Additive genetic heritability of ASP was 26% (p = 0.0004). Bivariate genetic analysis detected significant genetic correlations between ASP and several lipid measures but not between ASP and adiposity or diabetes measures. We detected two potential quantitative trait loci influencing ASP levels. The strongest signal was on chromosome 17 near marker D17S1303 [log of the odds ratio (LOD) = 2.7]. The signal on chromosome 15 reached its peak near marker D15S641 (LOD = 2.1). Both signals localize in regions reported to harbor quantitative trait loci influencing obesity and lipid phenotypes in this population. Bivariate linkage analysis yielded LODs of 4.7 for ASP and BMI on chromosome 17 and 3.2 for ASP and high-density lipoprotein2a on chromosome 15. Discussion: Given these findings, there seems to be a significant genetic contribution to variation in circulating levels of ASP and an interesting pattern of genetic correlation (i.e., pleiotropy) with other risk factors associated with the metabolic syndrome.

    Original languageEnglish (US)
    Pages (from-to)669-678
    Number of pages10
    JournalObesity Research
    Volume12
    Issue number4
    DOIs
    StatePublished - 2004

    Keywords

    • Acylation-stimulating protein
    • Adipokines
    • Bivariate linkage analysis
    • C3adesArg
    • Mexican Americans

    ASJC Scopus subject areas

    • Medicine (miscellaneous)
    • Food Science
    • Endocrinology, Diabetes and Metabolism
    • Endocrinology
    • Public Health, Environmental and Occupational Health

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