Bisphosphonates in the adjuvant treatment of cancer: Experimental evidence and first clinical results

I. J. Diel, G. R. Mundy

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations

Abstract

Several animal models, as well as a number of cell culture experiments, indicate a prophylactic effect of bisphosphonates in respect of subsequent bone metastasis. Moreover, in preliminary clinical trials involving patients with advanced breast cancer and local or remote metastases, biophosphonates produced a reduction in new skeletal metastases. This overview summarizes and discusses the results of the latest investigations. It opens with a section on the pathophysiology of bone metastasis, which is followed by a report on animal models and first studies of bisphosphonate treatment as a new approach in systemic adjuvant therapy. (C) 2000 Cancer Research Campaign.

Original languageEnglish (US)
Pages (from-to)1381-1386
Number of pages6
JournalBritish Journal of Cancer
Volume82
Issue number8
DOIs
StatePublished - 2000
Externally publishedYes

Keywords

  • Bisphosphonates
  • Bone metastases
  • Prevention
  • Prophylaxis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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