TY - JOUR
T1 - Bisphosphonates as cancer drugs
AU - Mundy, Gregory R.
PY - 1999/5/15
Y1 - 1999/5/15
N2 - Bone appears to act like fertilizer for many tumors, including myeloma and metastatic breast cancer. The explanation must lie in interactions between tumor cells and the bone-tissue microenvironment. At this level, too, must lie the explanation of how bisphosphonates address not only cancer osteolysis but also the tumor burden. By inhibiting osteoclasts, the drugs may block a cancer-related vicious cycle.
AB - Bone appears to act like fertilizer for many tumors, including myeloma and metastatic breast cancer. The explanation must lie in interactions between tumor cells and the bone-tissue microenvironment. At this level, too, must lie the explanation of how bisphosphonates address not only cancer osteolysis but also the tumor burden. By inhibiting osteoclasts, the drugs may block a cancer-related vicious cycle.
UR - http://www.scopus.com/inward/record.url?scp=0033562873&partnerID=8YFLogxK
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U2 - 10.3810/hp.1999.05.141
DO - 10.3810/hp.1999.05.141
M3 - Review article
C2 - 10340036
AN - SCOPUS:0033562873
SN - 2154-8331
VL - 34
SP - 81
EP - 94
JO - Hospital practice (1995)
JF - Hospital practice (1995)
IS - 5
ER -