Bisphosphonates as cancer drugs

Gregory R. Mundy

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


Bone appears to act like fertilizer for many tumors, including myeloma and metastatic breast cancer. The explanation must lie in interactions between tumor cells and the bone-tissue microenvironment. At this level, too, must lie the explanation of how bisphosphonates address not only cancer osteolysis but also the tumor burden. By inhibiting osteoclasts, the drugs may block a cancer-related vicious cycle.

Original languageEnglish (US)
Pages (from-to)81-94
Number of pages14
JournalHospital Practice
Issue number5
StatePublished - May 15 1999

ASJC Scopus subject areas

  • Medicine(all)


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