Bisphosphonate-related osteonecrosis of the mandible and maxilla: Clinical and imaging features

Sonia B. Gill, Maria P. Valencia, Mary Lou C. Sabino, Gregory M. Heideman, Michelle A. Michel

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

OBJECTIVE: Bisphosphonate-related osteonecrosis of the jaws is a rare, but morbid, condition. We present the clinical and imaging features of 19 patients. METHODS: A review of 19 bisphosphonate-related osteonecrosis patients was performed. Patient demographics, diagnosis, dental procedures, symptoms and clinical findings, location and pattern of involvement, and presence of fractures, sequestra, and fistulae were documented. RESULTS: Patients included 14 women and 5 men aged 48 to 80 years. Diagnoses included breast carcinoma (n = 11), multiple myeloma (n = 4), osteoporosis (n = 4), prostate carcinoma (n = 2), and lymphoma (n = 1). Seventeen patients received intravenous and 2 received oral bisphosphonates for 2 to 5 years. Bone involvement was noted in the mandible (74%), maxilla (16%), and both (10%). A lytic and sclerotic pattern was most common (58%). Additional findings included fractures (n = 5), sequestra (n = 4), and oroantral fistulae (n = 2). CONCLUSIONS: Bisphosphonate-related osteonecrosis is a rare, but morbid, condition, and imaging features can mimic other conditions. It is important for the radiologist to consider this entity in the appropriate clinical setting.

Original languageEnglish (US)
Pages (from-to)449-454
Number of pages6
JournalJournal of Computer Assisted Tomography
Volume33
Issue number3
DOIs
StatePublished - May 1 2009

Keywords

  • Bisphosphonates
  • Jaws
  • Mandible
  • Maxilla
  • Osteonecrosis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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