TY - JOUR
T1 - Biphasic action of growth hormone on intestinal amino acid absorption in striped bass hybrids
AU - Sun, L. Z.
AU - Farmanfarmaian, A.
N1 - Funding Information:
Acknowledgemenrs-We would like to thank Katharine Pugliese-Klinefeltefro r her skillful assistancien a numbero f experimentsW. e also thank Mr John Grazul for tissue electronm icroscopya nd MS BrendaM aitim for tissuel ight microscopy.T his researchw as supportedi n part by funds from theC enterf or Coastala nd EnvironmentaSl tudiesa nd the Bureauo f Biological Research,R utgersU niversity;N J Commissiono n Sciencea nd Technology;N J AES Project No. 32404t o A.F. and by an Anne B. and James H. LeathemS cholarshipt o L.-Z.S. L.-Z.S.w as supportedb y a Charlesa nd Johanna Busch PredoctoralF ellowship for I year.
PY - 1992/10
Y1 - 1992/10
N2 - 1. 1. Weekly injections of bovine growth hormone (bGH) increased the maximal transport rate of both Na+-dependent and Na+ -independent l-leucine transport with little effect on the affinity constants in the intestine of striped bass hybrids. 2. 2. The Na+-dependent and the Na+-independent transport of the non-metabolizable analog cycloleucine was also stimulated by bGH. 3. 3. The Na+ -dependent active transport was stimulated 2 days after the hormone treatment, while the stimulation of the Na+-independent diffusional transport was not observed until after 2 weeks of treatment. 4. 4. Studies of intestinal morphometry and l-leucine transport using brush border membrane vesicles suggested that bGH affects intestinal amino acid absorption initially by increasing the number of transporters per cell. 5. 5. This phase is followed by a general increase of the intestinal mass after long-term treatment with the hormone.
AB - 1. 1. Weekly injections of bovine growth hormone (bGH) increased the maximal transport rate of both Na+-dependent and Na+ -independent l-leucine transport with little effect on the affinity constants in the intestine of striped bass hybrids. 2. 2. The Na+-dependent and the Na+-independent transport of the non-metabolizable analog cycloleucine was also stimulated by bGH. 3. 3. The Na+ -dependent active transport was stimulated 2 days after the hormone treatment, while the stimulation of the Na+-independent diffusional transport was not observed until after 2 weeks of treatment. 4. 4. Studies of intestinal morphometry and l-leucine transport using brush border membrane vesicles suggested that bGH affects intestinal amino acid absorption initially by increasing the number of transporters per cell. 5. 5. This phase is followed by a general increase of the intestinal mass after long-term treatment with the hormone.
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U2 - 10.1016/0300-9629(92)90598-K
DO - 10.1016/0300-9629(92)90598-K
M3 - Article
AN - SCOPUS:0026794322
VL - 103
SP - 381
EP - 390
JO - Comparative Biochemistry and Physiology -- Part A: Physiology
JF - Comparative Biochemistry and Physiology -- Part A: Physiology
SN - 0300-9629
IS - 2
ER -