Biosensor technology in aging research and age-related diseases

Yulong He; Yuehong Wu; Anuja Mishra; Victor Acha; Thomas Andrews; Peter J. Hornsby

doi:10.1016/j.arr.2011.11.004

Biosensor technology in aging research and age-related diseases

Yulong He, Yuehong Wu, Anuja Mishra, Victor Acha, Thomas Andrews, Peter J. Hornsby

Department of Cellular & Integrative Physiology

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Cell- and tissue-based biosensors comprise genetically engineered proteins that are incorporated into cells ex vivo or into cells of tissues in vivo. They enable the investigator to sense levels of hormones, drugs, or toxins, continuously and noninvasively, using biophotonics or other physical principles, and could potentially be used over the entire lifespan of an experimental animal. The present work reviews the state of the art of cell- and tissue-based biosensors and discusses how they could be of value in aging research. Examples of recently developed biosensors are given, including those that detect levels of a cytokine (TNFα) and drugs (activators of the mTOR pathway). Finally, we discuss the hurdles that would have to be overcome for biosensor technology to be used in humans in monitoring health status and disease treatment in late life.

Original language	English (US)
Pages (from-to)	1-9
Number of pages	9
Journal	Ageing Research Reviews
Volume	11
Issue number	1
DOIs	https://doi.org/10.1016/j.arr.2011.11.004
State	Published - Jan 2012

Keywords

Biophotonics
Biosensors
Lifespan
Luciferases
MTOR
TNFα

ASJC Scopus subject areas

Neurology
Aging
Molecular Biology
Biochemistry
Biotechnology

Access to Document

10.1016/j.arr.2011.11.004

Cite this

@article{a7c36192f81744e684d0eea1ccc362ca,

title = "Biosensor technology in aging research and age-related diseases",

abstract = "Cell- and tissue-based biosensors comprise genetically engineered proteins that are incorporated into cells ex vivo or into cells of tissues in vivo. They enable the investigator to sense levels of hormones, drugs, or toxins, continuously and noninvasively, using biophotonics or other physical principles, and could potentially be used over the entire lifespan of an experimental animal. The present work reviews the state of the art of cell- and tissue-based biosensors and discusses how they could be of value in aging research. Examples of recently developed biosensors are given, including those that detect levels of a cytokine (TNFα) and drugs (activators of the mTOR pathway). Finally, we discuss the hurdles that would have to be overcome for biosensor technology to be used in humans in monitoring health status and disease treatment in late life.",

keywords = "Biophotonics, Biosensors, Lifespan, Luciferases, MTOR, TNFα",

author = "Yulong He and Yuehong Wu and Anuja Mishra and Victor Acha and Thomas Andrews and Hornsby, {Peter J.}",

note = "Funding Information: This work was supported by a grant from the San Antonio Life Sciences Institute . Work on the mTOR biosensor was supported by a pilot grant from the San Antonio Nathan Shock Aging Center (National Institute on Aging grant P30AG013319 ).",

year = "2012",

month = jan,

doi = "10.1016/j.arr.2011.11.004",

language = "English (US)",

volume = "11",

pages = "1--9",

journal = "Ageing Research Reviews",

issn = "1568-1637",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - Biosensor technology in aging research and age-related diseases

AU - He, Yulong

AU - Wu, Yuehong

AU - Mishra, Anuja

AU - Acha, Victor

AU - Andrews, Thomas

AU - Hornsby, Peter J.

N1 - Funding Information: This work was supported by a grant from the San Antonio Life Sciences Institute . Work on the mTOR biosensor was supported by a pilot grant from the San Antonio Nathan Shock Aging Center (National Institute on Aging grant P30AG013319 ).

PY - 2012/1

Y1 - 2012/1

N2 - Cell- and tissue-based biosensors comprise genetically engineered proteins that are incorporated into cells ex vivo or into cells of tissues in vivo. They enable the investigator to sense levels of hormones, drugs, or toxins, continuously and noninvasively, using biophotonics or other physical principles, and could potentially be used over the entire lifespan of an experimental animal. The present work reviews the state of the art of cell- and tissue-based biosensors and discusses how they could be of value in aging research. Examples of recently developed biosensors are given, including those that detect levels of a cytokine (TNFα) and drugs (activators of the mTOR pathway). Finally, we discuss the hurdles that would have to be overcome for biosensor technology to be used in humans in monitoring health status and disease treatment in late life.

AB - Cell- and tissue-based biosensors comprise genetically engineered proteins that are incorporated into cells ex vivo or into cells of tissues in vivo. They enable the investigator to sense levels of hormones, drugs, or toxins, continuously and noninvasively, using biophotonics or other physical principles, and could potentially be used over the entire lifespan of an experimental animal. The present work reviews the state of the art of cell- and tissue-based biosensors and discusses how they could be of value in aging research. Examples of recently developed biosensors are given, including those that detect levels of a cytokine (TNFα) and drugs (activators of the mTOR pathway). Finally, we discuss the hurdles that would have to be overcome for biosensor technology to be used in humans in monitoring health status and disease treatment in late life.

KW - Biophotonics

KW - Biosensors

KW - Lifespan

KW - Luciferases

KW - MTOR

KW - TNFα

UR - http://www.scopus.com/inward/record.url?scp=83855162145&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=83855162145&partnerID=8YFLogxK

U2 - 10.1016/j.arr.2011.11.004

DO - 10.1016/j.arr.2011.11.004

M3 - Review article

C2 - 22115588

AN - SCOPUS:83855162145

SN - 1568-1637

VL - 11

SP - 1

EP - 9

JO - Ageing Research Reviews

JF - Ageing Research Reviews

IS - 1

ER -

Biosensor technology in aging research and age-related diseases

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this