TY - JOUR
T1 - Biomechanical characterization of vaginal versus abdominal surgical wound healing in the rabbit
AU - Abramov, Yoram
AU - Webb, Antonio R.
AU - Miller, Jay James R.
AU - Alshahrour, Adeeb
AU - Botros, Sylvia M.
AU - Goldberg, Roger P.
AU - Ameer, Guillermo A.
AU - Sand, Peter K.
N1 - Funding Information:
Supported by an institutional research grant from the Department of Obstetrics and Gynecology, Evanston Northwestern Healthcare, Evanston, IL.
PY - 2006/5
Y1 - 2006/5
N2 - Objective: The objective of the study was to compare biomechanical properties of vaginal versus abdominal surgical wound healing in the rabbit. Study design: Bilateral 6-mm full-thickness circular segments were excised from the vagina and abdominal skin in 38 New Zealand White female rabbits. Animals were killed 0, 4, 7, 10, 14, 21, 28, and 35 days after wounding, and the wounds were assessed for surface area and tensile properties. Results: Wound closure and scar contraction were significantly faster in the vagina than the abdomen (P = .001). Baseline tensile strength (P = .05), modulus (P = .001), and tensile energy to break (P = .18) were higher in the abdomen, whereas maximal tissue elongation was higher in the vagina (P = .13). After wounding, a drop in tensile strength, modulus, and tensile energy to break was observed in both tissues through postwounding day 4, followed by a progressive recovery of these properties. A progressive loss of elasticity was noted in both tissues after wounding. Conclusion: The surgical wound closes and contracts faster in the rabbit vagina than in its abdomen. Although these tissues have different biomechanical properties at baseline, they regenerate their tensile strength and lose their elasticity at a similar rate.
AB - Objective: The objective of the study was to compare biomechanical properties of vaginal versus abdominal surgical wound healing in the rabbit. Study design: Bilateral 6-mm full-thickness circular segments were excised from the vagina and abdominal skin in 38 New Zealand White female rabbits. Animals were killed 0, 4, 7, 10, 14, 21, 28, and 35 days after wounding, and the wounds were assessed for surface area and tensile properties. Results: Wound closure and scar contraction were significantly faster in the vagina than the abdomen (P = .001). Baseline tensile strength (P = .05), modulus (P = .001), and tensile energy to break (P = .18) were higher in the abdomen, whereas maximal tissue elongation was higher in the vagina (P = .13). After wounding, a drop in tensile strength, modulus, and tensile energy to break was observed in both tissues through postwounding day 4, followed by a progressive recovery of these properties. A progressive loss of elasticity was noted in both tissues after wounding. Conclusion: The surgical wound closes and contracts faster in the rabbit vagina than in its abdomen. Although these tissues have different biomechanical properties at baseline, they regenerate their tensile strength and lose their elasticity at a similar rate.
KW - Abdominal skin
KW - Biomechanical properties
KW - Surgical wound healing
KW - Vagina
UR - http://www.scopus.com/inward/record.url?scp=33646091737&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646091737&partnerID=8YFLogxK
U2 - 10.1016/j.ajog.2006.01.063
DO - 10.1016/j.ajog.2006.01.063
M3 - Article
C2 - 16647930
AN - SCOPUS:33646091737
SN - 0002-9378
VL - 194
SP - 1472
EP - 1477
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 5
ER -