Biomarker testing to estimate under-reported heavy alcohol consumption by persons with HIV initiating ART in Uganda

Judith A. Hahn; Mwebesa B. Bwana; Martin A. Javors; Jeffrey N. Martin; Nneka I. Emenyonu; David R. Bangsberg

doi:10.1007/s10461-010-9768-y

Biomarker testing to estimate under-reported heavy alcohol consumption by persons with HIV initiating ART in Uganda

Judith A. Hahn, Mwebesa B. Bwana, Martin A. Javors, Jeffrey N. Martin, Nneka I. Emenyonu, David R. Bangsberg

Department of Psychiatry & Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Alcohol affects the transmission and treatment of HIV, yet may be under-reported in resource-limited settings. We compared self-reported alcohol consumption with levels of plasma carbohydrate-deficient transferrin (%CDT), a biomarker of heavy alcohol consumption, in persons initiating antiretroviral therapy in Uganda. Almost seven percent (6.7%) of persons reporting abstaining and 10% reporting consuming 1-40 drinks in the prior month tested positive for %CDT, and actual under-report may be higher due to low sensitivity of %CDT. These results suggest likely under-report in those reporting abstaining and current drinking. Improved identification of heavy alcohol consumption is needed for research and clinical purposes.

Original language	English (US)
Pages (from-to)	1265-1268
Number of pages	4
Journal	AIDS and Behavior
Volume	14
Issue number	6
DOIs	https://doi.org/10.1007/s10461-010-9768-y
State	Published - Dec 2010

Keywords

Alcohol drinking
Antiretroviral therapy
Biological markers
Carbohydrate-deficient transferrin
HIV
Uganda

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Infectious Diseases
Social Psychology

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10.1007/s10461-010-9768-y

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title = "Biomarker testing to estimate under-reported heavy alcohol consumption by persons with HIV initiating ART in Uganda",

abstract = "Alcohol affects the transmission and treatment of HIV, yet may be under-reported in resource-limited settings. We compared self-reported alcohol consumption with levels of plasma carbohydrate-deficient transferrin (%CDT), a biomarker of heavy alcohol consumption, in persons initiating antiretroviral therapy in Uganda. Almost seven percent (6.7%) of persons reporting abstaining and 10% reporting consuming 1-40 drinks in the prior month tested positive for %CDT, and actual under-report may be higher due to low sensitivity of %CDT. These results suggest likely under-report in those reporting abstaining and current drinking. Improved identification of heavy alcohol consumption is needed for research and clinical purposes.",

keywords = "Alcohol drinking, Antiretroviral therapy, Biological markers, Carbohydrate-deficient transferrin, HIV, Uganda",

author = "Hahn, {Judith A.} and Bwana, {Mwebesa B.} and Javors, {Martin A.} and Martin, {Jeffrey N.} and Emenyonu, {Nneka I.} and Bangsberg, {David R.}",

note = "Funding Information: Acknowledgment This study was supported by NIH R01 MH54907 and Hellman Family Award for Early Career Investigator.",

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AU - Hahn, Judith A.

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AU - Javors, Martin A.

AU - Martin, Jeffrey N.

AU - Emenyonu, Nneka I.

AU - Bangsberg, David R.

N1 - Funding Information: Acknowledgment This study was supported by NIH R01 MH54907 and Hellman Family Award for Early Career Investigator.

PY - 2010/12

Y1 - 2010/12

N2 - Alcohol affects the transmission and treatment of HIV, yet may be under-reported in resource-limited settings. We compared self-reported alcohol consumption with levels of plasma carbohydrate-deficient transferrin (%CDT), a biomarker of heavy alcohol consumption, in persons initiating antiretroviral therapy in Uganda. Almost seven percent (6.7%) of persons reporting abstaining and 10% reporting consuming 1-40 drinks in the prior month tested positive for %CDT, and actual under-report may be higher due to low sensitivity of %CDT. These results suggest likely under-report in those reporting abstaining and current drinking. Improved identification of heavy alcohol consumption is needed for research and clinical purposes.

AB - Alcohol affects the transmission and treatment of HIV, yet may be under-reported in resource-limited settings. We compared self-reported alcohol consumption with levels of plasma carbohydrate-deficient transferrin (%CDT), a biomarker of heavy alcohol consumption, in persons initiating antiretroviral therapy in Uganda. Almost seven percent (6.7%) of persons reporting abstaining and 10% reporting consuming 1-40 drinks in the prior month tested positive for %CDT, and actual under-report may be higher due to low sensitivity of %CDT. These results suggest likely under-report in those reporting abstaining and current drinking. Improved identification of heavy alcohol consumption is needed for research and clinical purposes.

KW - Alcohol drinking

KW - Antiretroviral therapy

KW - Biological markers

KW - Carbohydrate-deficient transferrin

KW - HIV

KW - Uganda

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Biomarker testing to estimate under-reported heavy alcohol consumption by persons with HIV initiating ART in Uganda

Abstract

Keywords

ASJC Scopus subject areas

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