Biology of metabolic syndrome in a vascular patient

Daynene Vykoukal, Mark G. Davies

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Metabolic syndrome is highly prevalent in vascular patients and has a significant impact on the outcomes of vascular interventions. It comprises of a set of metabolically driven risk factors, including truncal obesity, dyslipidemia, elevated blood pressure and elevated fasting blood glucose. Increased insulin resistance within the context of obesity and hypertension contributes to atherogenic dyslipidemia, hyperglycemia, and prothrombotic and proinflammatory states which lead to the adverse impact of metabolic syndrome on the response to injury and on atherosclerotic disease progression. This review focuses on the complex biology of metabolic syndrome and its relevance to management of vascular patients, including outcomes and implications for the coronary, cerebrovascular and lower-extremity vascular beds.

Original languageEnglish (US)
Pages (from-to)156-163
Number of pages8
JournalVascular
Volume20
Issue number3
DOIs
StatePublished - Jun 1 2012
Externally publishedYes

Keywords

  • Adipokines
  • Insulin resistance
  • Metabolic syndrome
  • Obesity
  • Vascular biology

ASJC Scopus subject areas

  • Surgery
  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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