The biology of aortic aneurysm and dissection has evolved to where we now understand the genetic implications of changes in extracellular matrix proteins, smooth muscle cells, and growth factors and how they affect aortic wall homeostasis. These predeterminants are influenced by smoking, hypertension, and atherosclerosis, and the result in an inflammatory response coupled to an accelerated proteolytic cascade that disrupts both elastin and collagen in the aortic wall.
|Original language||English (US)|
|Number of pages||6|
|Journal||Methodist DeBakey cardiovascular journal|
|State||Published - 2011|
ASJC Scopus subject areas