Biology of aortic aneurysms and dissections.

Joseph S. Fernandez-Moure, Daynene Vykoukal, Mark G. Davies

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

The biology of aortic aneurysm and dissection has evolved to where we now understand the genetic implications of changes in extracellular matrix proteins, smooth muscle cells, and growth factors and how they affect aortic wall homeostasis. These predeterminants are influenced by smoking, hypertension, and atherosclerosis, and the result in an inflammatory response coupled to an accelerated proteolytic cascade that disrupts both elastin and collagen in the aortic wall.

Original languageEnglish (US)
Pages (from-to)2-7
Number of pages6
JournalMethodist DeBakey cardiovascular journal
Volume7
Issue number3
DOIs
StatePublished - 2011
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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