Biological variation of total, free and percent free serum prostate specific antigen levels in screening volunteers

David K. Ornstein, Deborah S. Smith, Ganesh S. Rao, Joseph W. Basler, Timothy L. Ratliff, William J. Catalona

Research output: Contribution to journalArticle

75 Scopus citations

Abstract

Purpose: We determined the biological variation of the total, free and percent free serum prostate specific antigen (PSA) in men 50 years old or older. Materials and Methods: Between July 1995 and February 1996 we studied 84 healthy men from our PSA screening study to determine biological variation by calculating the coefficients of variation of 3 PSA measurements on blood samples drawn from each subject 2 weeks apart. Results: The mean coefficients of variation for total, free and percent free serum PSA were 15, 17 and 14%, respectively. Age, total PSA and ejaculation were not confounding factors in this analysis (that is multivariate R2 less than 5% for all indexes). Conclusions: There is a mean variation of approximately 15% in measurements of total, free and percent free PSA that does not appear to be significantly affected by age and total PSA level.

Original languageEnglish (US)
Pages (from-to)2179-2182
Number of pages4
JournalJournal of Urology
Volume157
Issue number6
DOIs
StatePublished - Jun 1997
Externally publishedYes

Keywords

  • ejaculation
  • prostate
  • prostate-specific antigen
  • prostatic neoplasms

ASJC Scopus subject areas

  • Urology

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