TY - JOUR
T1 - Biological evidence for a neurodevelopmental model of pediatric bipolar disorder
AU - Roybal, Donna J.
AU - Singh, Manpreet K.
AU - Cosgrove, Victoria E.
AU - Howe, Meghan
AU - Kelley, Ryan
AU - Barnea-Goraly, Naama
AU - Chang, Kiki D.
PY - 2012/8/2
Y1 - 2012/8/2
N2 - Bipolar disorder (BD) is a chronic illness with high morbidity and mortality. Pediatric onset BD has a more severe course of illness with higher rates of relapse and psychosocial impairment. Discovering interventions early in the course of BD in youth is paramount to preventing full illness expression and improve functioning in these individuals throughout the lifespan. It is therefore important to understand the mechanisms involved in the development of BD in order to determine which youth are at most risk and provide biological targets for early intervention. To serve this cause, we propose a neurodevelopmental model of BD, based on the existing data that implicate prefrontal - subcortical network dysfunction, caused by pre-existing genetic susceptibility and triggered by pathological reactions to stress and chronic inflammatory processes.
AB - Bipolar disorder (BD) is a chronic illness with high morbidity and mortality. Pediatric onset BD has a more severe course of illness with higher rates of relapse and psychosocial impairment. Discovering interventions early in the course of BD in youth is paramount to preventing full illness expression and improve functioning in these individuals throughout the lifespan. It is therefore important to understand the mechanisms involved in the development of BD in order to determine which youth are at most risk and provide biological targets for early intervention. To serve this cause, we propose a neurodevelopmental model of BD, based on the existing data that implicate prefrontal - subcortical network dysfunction, caused by pre-existing genetic susceptibility and triggered by pathological reactions to stress and chronic inflammatory processes.
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M3 - Article
C2 - 22652927
AN - SCOPUS:84864381318
VL - 49
SP - 28
EP - 43
JO - Israel Journal of Psychiatry and Related Sciences
JF - Israel Journal of Psychiatry and Related Sciences
SN - 0333-7308
IS - 1
ER -