Biological component of the NIMH clinical research branch collaborative program on the psychobiology of depression: I. Background and theoretical considerations.

J. W. Maas, S. H. Koslow, J. M. Davis, M. M. Katz, J. Mendels, E. Robins, P. E. Stokes, C. L. Bowden

Research output: Contribution to journalArticle

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Abstract

There are many reports which suggest that patients with effective illness (mania and/or depression) have abnormalities in the functioning of one or more neurobiological systems. At a conference convened by the Clinical Research Branch, Division of Extramural Research Programs, National Institute of Mental Health, these findings were reviewed and some of the factors impeding movement towards a more complete and integrated view of the functioning of neurobiological systems in patients with mania or depression were identified. As a result, a multi-research centre, collaborative approach to the study of the psychobiology of affective disorders was developed. In this collaborative programme, which has now been underway for several years, the focus has been upon: (a) the assessment of the functioning of several different types of biological systems in the same patient, both before and during treatment; (b) obtaining a reasonably large number of patients and comparison subjects; and (c) the use within and across centres of standardized diagnostic categories and behavioural rating methodologies. In this paper the history, background, and rationale for this collaborative effort are reviewed. Those biological systems chosen for study are noted, and issues such as reliability and validity of diagnoses, measurement of state variables, assessment of change with treatment, and logistical and coordinating problems are discussed.

Original languageEnglish (US)
Pages (from-to)759-776
Number of pages18
JournalPsychological Medicine
Volume10
Issue number4
StatePublished - Nov 1980

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National Institute of Mental Health (U.S.)
Depression
Bipolar Disorder
Research
Mood Disorders
Reproducibility of Results
History
Therapeutics

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Psychology(all)
  • Clinical Psychology

Cite this

Maas, J. W., Koslow, S. H., Davis, J. M., Katz, M. M., Mendels, J., Robins, E., ... Bowden, C. L. (1980). Biological component of the NIMH clinical research branch collaborative program on the psychobiology of depression: I. Background and theoretical considerations. Psychological Medicine, 10(4), 759-776.

Biological component of the NIMH clinical research branch collaborative program on the psychobiology of depression : I. Background and theoretical considerations. / Maas, J. W.; Koslow, S. H.; Davis, J. M.; Katz, M. M.; Mendels, J.; Robins, E.; Stokes, P. E.; Bowden, C. L.

In: Psychological Medicine, Vol. 10, No. 4, 11.1980, p. 759-776.

Research output: Contribution to journalArticle

Maas, JW, Koslow, SH, Davis, JM, Katz, MM, Mendels, J, Robins, E, Stokes, PE & Bowden, CL 1980, 'Biological component of the NIMH clinical research branch collaborative program on the psychobiology of depression: I. Background and theoretical considerations.', Psychological Medicine, vol. 10, no. 4, pp. 759-776.
Maas, J. W. ; Koslow, S. H. ; Davis, J. M. ; Katz, M. M. ; Mendels, J. ; Robins, E. ; Stokes, P. E. ; Bowden, C. L. / Biological component of the NIMH clinical research branch collaborative program on the psychobiology of depression : I. Background and theoretical considerations. In: Psychological Medicine. 1980 ; Vol. 10, No. 4. pp. 759-776.
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