Biological characterization of human monoclonal antibodies to rabies virus

B. Dietzschold, M. Gore, P. Casali, Y. Ueki, C. E. Rupprecht, A. L. Notkins, H. Koprowski

Research output: Contribution to journalArticlepeer-review

76 Scopus citations

Abstract

Rabies virus antigen-specific human monoclonal antibodies (MAbs) that recognized either viral glycoprotein, ribonucleoprotein, or matrix proteins were generated. Only glycoprotein-specific MAb neutralized a variety of rabies viruses and protected laboratory rodents against lethal rabies virus infection. The determinant recognized this MAb does not appear to reside in previously defined antigenic sites of the viral glycoprotein.

Original languageEnglish (US)
Pages (from-to)3087-3090
Number of pages4
JournalJournal of virology
Volume64
Issue number6
DOIs
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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