Biological characterization of human monoclonal antibodies to rabies virus

B. Dietzschold; M. Gore; P. Casali; Y. Ueki; C. E. Rupprecht; A. L. Notkins; H. Koprowski

doi:10.1128/jvi.64.6.3087-3090.1990

Biological characterization of human monoclonal antibodies to rabies virus

B. Dietzschold, M. Gore, P. Casali, Y. Ueki, C. E. Rupprecht, A. L. Notkins, H. Koprowski

Research output: Contribution to journal › Article › peer-review

85 Scopus citations

Abstract

Rabies virus antigen-specific human monoclonal antibodies (MAbs) that recognized either viral glycoprotein, ribonucleoprotein, or matrix proteins were generated. Only glycoprotein-specific MAb neutralized a variety of rabies viruses and protected laboratory rodents against lethal rabies virus infection. The determinant recognized this MAb does not appear to reside in previously defined antigenic sites of the viral glycoprotein.

Original language	English (US)
Pages (from-to)	3087-3090
Number of pages	4
Journal	Journal of virology
Volume	64
Issue number	6
DOIs	https://doi.org/10.1128/jvi.64.6.3087-3090.1990
State	Published - 1990
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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10.1128/jvi.64.6.3087-3090.1990

Cite this

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abstract = "Rabies virus antigen-specific human monoclonal antibodies (MAbs) that recognized either viral glycoprotein, ribonucleoprotein, or matrix proteins were generated. Only glycoprotein-specific MAb neutralized a variety of rabies viruses and protected laboratory rodents against lethal rabies virus infection. The determinant recognized this MAb does not appear to reside in previously defined antigenic sites of the viral glycoprotein.",

author = "B. Dietzschold and M. Gore and P. Casali and Y. Ueki and Rupprecht, {C. E.} and Notkins, {A. L.} and H. Koprowski",

year = "1990",

doi = "10.1128/jvi.64.6.3087-3090.1990",

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AU - Dietzschold, B.

AU - Gore, M.

AU - Casali, P.

AU - Ueki, Y.

AU - Rupprecht, C. E.

AU - Notkins, A. L.

AU - Koprowski, H.

PY - 1990

Y1 - 1990

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AB - Rabies virus antigen-specific human monoclonal antibodies (MAbs) that recognized either viral glycoprotein, ribonucleoprotein, or matrix proteins were generated. Only glycoprotein-specific MAb neutralized a variety of rabies viruses and protected laboratory rodents against lethal rabies virus infection. The determinant recognized this MAb does not appear to reside in previously defined antigenic sites of the viral glycoprotein.

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DO - 10.1128/jvi.64.6.3087-3090.1990

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Biological characterization of human monoclonal antibodies to rabies virus

Abstract

ASJC Scopus subject areas

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