Biological characterization of human monoclonal antibodies to rabies virus

Bernhard Dietzschold; Milind Gore; Paolo Casali; Yuji Ueki; Charles E. Rupprecht; Abner L. Notkins; Hilary Koprowski

Biological characterization of human monoclonal antibodies to rabies virus

Bernhard Dietzschold, Milind Gore, Paolo Casali, Yuji Ueki, Charles E. Rupprecht, Abner L. Notkins, Hilary Koprowski

Research output: Contribution to journal › Article › peer-review

Abstract

Rabies virus antigen-specific human monoclonal antibodies (MAbs) that recognized either viral glycoprotein, ribonucleoprotein, or matrix proteins were generated. Only glycoprotein-specific MAb neutralized a variety of rabies viruses and protected laboratory rodents against lethal rabies virus infection. The determinant recognized by this MAb does not appear to reside in previously defined antigenic sites of the viral glycoprotein.

Original language	English (US)
Pages (from-to)	3087-3090
Number of pages	4
Journal	Journal of virology
Volume	64
Issue number	6
State	Published - 1990
Externally published	Yes

ASJC Scopus subject areas

Insect Science
Virology
Microbiology
Immunology

Cite this

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title = "Biological characterization of human monoclonal antibodies to rabies virus",

abstract = "Rabies virus antigen-specific human monoclonal antibodies (MAbs) that recognized either viral glycoprotein, ribonucleoprotein, or matrix proteins were generated. Only glycoprotein-specific MAb neutralized a variety of rabies viruses and protected laboratory rodents against lethal rabies virus infection. The determinant recognized by this MAb does not appear to reside in previously defined antigenic sites of the viral glycoprotein.",

author = "Bernhard Dietzschold and Milind Gore and Paolo Casali and Yuji Ueki and Rupprecht, {Charles E.} and Notkins, {Abner L.} and Hilary Koprowski",

year = "1990",

language = "English (US)",

volume = "64",

pages = "3087--3090",

journal = "Journal of virology",

issn = "0022-538X",

publisher = "American Society for Microbiology",

number = "6",

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TY - JOUR

T1 - Biological characterization of human monoclonal antibodies to rabies virus

AU - Dietzschold, Bernhard

AU - Gore, Milind

AU - Casali, Paolo

AU - Ueki, Yuji

AU - Rupprecht, Charles E.

AU - Notkins, Abner L.

AU - Koprowski, Hilary

PY - 1990

Y1 - 1990

N2 - Rabies virus antigen-specific human monoclonal antibodies (MAbs) that recognized either viral glycoprotein, ribonucleoprotein, or matrix proteins were generated. Only glycoprotein-specific MAb neutralized a variety of rabies viruses and protected laboratory rodents against lethal rabies virus infection. The determinant recognized by this MAb does not appear to reside in previously defined antigenic sites of the viral glycoprotein.

AB - Rabies virus antigen-specific human monoclonal antibodies (MAbs) that recognized either viral glycoprotein, ribonucleoprotein, or matrix proteins were generated. Only glycoprotein-specific MAb neutralized a variety of rabies viruses and protected laboratory rodents against lethal rabies virus infection. The determinant recognized by this MAb does not appear to reside in previously defined antigenic sites of the viral glycoprotein.

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M3 - Article

C2 - 2335829

AN - SCOPUS:0025369456

SN - 0022-538X

VL - 64

SP - 3087

EP - 3090

JO - Journal of virology

JF - Journal of virology

IS - 6

ER -

Biological characterization of human monoclonal antibodies to rabies virus

Abstract

ASJC Scopus subject areas

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