Biogenic amines in the reduction of oxidative stress: Melatonin and its metabolites

Russel J. Reiter, Dun Xian Tan, Mei Jie Jou, Ahmet Korkmaz, Lucien C. Manchester, Sergio D. Paredes

Research output: Contribution to journalReview articlepeer-review

99 Scopus citations


N-acetyl-5-methoxytryptamine (melatonin) is an endogenous indoleamine produced by all vertebrate organisms. Its production in the pineal gland has been extensively investigated but other organs also synthesize this important amine. Melatonin's functions in organisms are diverse. The actions considered in the current review relate to its ability to function in the reduction of oxidative stress, i.e., molecular damage produced by reactive oxygen and reactive nitrogen species. Numerous publications have now shown that not only is melatonin itself an efficient scavenger of free radicals and related reactants, but so are its by-products cyclic 3-hydroxymelatonin, N1-acetyl-N2-formyl-5-methoxykynuramine, and others. These derivatives are produced sequentially when each functions in the capacity of a free radical scavenger. These successive reactions are referred to as the antioxidant cascade of melatonin. That melatonin has this function within cells has been observed in studies employing time lapse conventional, confocal and multiphoton fluorescent microscopy coupled with the use of appropriate mitochondrial-targeted fluorescent probes. The benefits of melatonin and its metabolites have been described in the brain where they are found to be protective in models of Parkinson's disease, Alzheimer's disease and spinal cord injury. The reader is reminded, however, that data not covered in this review has documented beneficial actions of these amines in every organ where they have been tested. The outlook for the use of melatonin in clinical trials looks encouraging given its low toxicity and high efficacy.

Original languageEnglish (US)
Pages (from-to)391-398
Number of pages8
JournalNeuroendocrinology Letters
Issue number4
StatePublished - Aug 2008


  • Antioxidant
  • Central nervous system
  • Melatonin
  • N1-acetyl-5-methoxykynuramine
  • N1-acetyl-N2-formyl-5-methoxykynuramine
  • Oxidative stress

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Psychiatry and Mental health


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