Biogenic amine metabolites in cerebrospinal fluid of depressed and manic patients

J. Mendels, A. Frazer, R. G. Fitzgerald, T. A. Ramsey, J. W. Stokes

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Abstract

A reduction in 5-hydroxyindoleacetic acid in cerebrospinal fluid was found in depressed and manic patients both while they were symptomatic and also after treatment. The concentration of homovanillic acid was initially reduced and then tended to increase after treatment.

Original languageEnglish (US)
Pages (from-to)1380-1382
Number of pages3
JournalScience
Volume175
Issue number4028
DOIs
Publication statusPublished - Jan 1 1972

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Mendels, J., Frazer, A., Fitzgerald, R. G., Ramsey, T. A., & Stokes, J. W. (1972). Biogenic amine metabolites in cerebrospinal fluid of depressed and manic patients. Science, 175(4028), 1380-1382. https://doi.org/10.1126/science.175.4028.1380