Biofilm: The microbial "bunker" for intravascular catheter-related infection

Manuel Morales, Sebastián Méndez-Alvarez, Juana Victoria Martín-López, Carmen Marrero, César O. Freytes

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


Catheter-related infection in cancer patients remains an important health-care problem with major financial implications. During the last few years a better understanding of the pathogenesis of catheter-related infections and the interaction between microorganisms and catheter surfaces has emerged. Recently the influence of biofilm formation in catheter-related infections has been established. The development of biofilm by the colonizing microbes permits attachment of the organisms to the vascular access device and confers resistance to antibiotics and host defense mechanisms. Strategies to overcome the development of biofilm are being developed to prevent catheter- and other medical device-related infections.

Original languageEnglish (US)
Pages (from-to)701-707
Number of pages7
JournalSupportive Care in Cancer
Issue number10
StatePublished - Oct 2004


  • Biofilm
  • Catheter-related infection
  • Polysaccharide intercellular adhesin (PIA)
  • ica-gene cluster

ASJC Scopus subject areas

  • Oncology


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