Biochemical markers for the prediction of preterm birth

Robert L. Goldenberg, Alice R. Goepfert, Patrick S. Ramsey

Research output: Contribution to journalArticlepeer-review

136 Scopus citations


The prediction of preterm birth may be important (1) to initiate risk specific treatment; (2) to define a population that is at risk in which to study a particular treatment; or (3) to better understand the pathways that lead to preterm birth. Biologic fluids that have been used as sources for tests include serum, plasma, amniotic fluid, urine, vaginal and cervical secretions, saliva, and even periodontal fluid. We discuss the types of substances that are found in body fluids (eg, organisms, cytokines, enzymes, hormones) that have been studied as predictors of preterm birth, the fluids in which they are found, and issues that are related to the timing of the test, the cost, and the ease of fluid collection and processing. We emphasize that a test for any of these substances should not be introduced into clinical practice until the use of the test, which is followed by an appropriate intervention, leads to a reduction in preterm birth.

Original languageEnglish (US)
Pages (from-to)S36-S46
JournalAmerican Journal of Obstetrics and Gynecology
Issue number5 SPEC. ISS.
StatePublished - May 2005
Externally publishedYes


  • Biologic fluid
  • Preterm birth

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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