Biochemical and white blood cell profiles of baboon neonates consuming formulas with moderate and high dietary long-chain polyunsaturated fatty acids

A. T. Hsieh, J. C. Anthony, D. A. Diersen-Schade, P. W. Nathanielsz, J. Thomas Brenna

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Background: Clinical chemistry and complete blood count (CBC) values were determined in 14 term baboons (Papio species) consuming formula with moderate or high levels of dietary long-chain polyunsaturated fatty acids (LCPUFA) from 2-12 weeks of age. Method: Neonates were randomized to three groups: C: Control, no LCPUFA; L: 0.33% docosahexaenoic acid (DHA)/0.67% arachidonic acid (ARA) (w/w); L3:1.00% DHA/0.67% ARA (w/w). Blood chemistries were assessed at 6 and 12 weeks and CBC parameters were measured at 2, 4, 8, 10, 12 weeks of age. Results: Dietary LCPUFA had significant effects on serum triglyceride (C > L,L3) and calcium (L > C,L3). No other significant effects of diet were detected; pooled values are presented for all other parameters. Conclusion: These data provide longitudinal biochemical and white cell/platelet/immunological data on LCPUFA-fed baboons over the first 12 weeks of life. Data ranges are similar to reference data in cases for which values exist and hematological changes reflect trends observed during human neonatal development.

Original languageEnglish (US)
Pages (from-to)81-87
Number of pages7
JournalJournal of medical primatology
Volume37
Issue number2
DOIs
StatePublished - Apr 1 2008

Keywords

  • Arachidonic acid
  • Blood reference ranges
  • Docosahexaenoic acid
  • Infant
  • Non-human primate

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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