Chronic lead administration leads to serious impairment of renal function. In order to study the underlying mechanisms, the changes in whole kidney and renal brush border enzymes-namely, alkaline phosphatase and succinic dehydrogenase-were estimated both after short-term exposures of 15 days and prolonged administration of 2 and 3 months. Lead acetate as 5 mg, 10 mg and 50 mg/kg body weight, was administered in a single dose orally on every alternate day. A significant decrease in the activity of alkaline phosphatase was seen initially when lead was given for 15 days, but following prolonged administration the activity increased. Similarly, succinic dehydrogenase activity decreased initially when lead was given for a shorter duration (15 days), but after 2 and 3 months of exposure, the values increased significantly. Histopathological observations revealed renal proliferation and degeneration occurring at a high dose of lead acetate (50 mg/kg body weight). The enzymatic findings imply that an adaptive mechanism comes into play at the two higher levels of lead exposure.
|Original language||English (US)|
|Number of pages||7|
|Journal||Journal of Trace Elements in Experimental Medicine|
|State||Published - Dec 1 1991|
ASJC Scopus subject areas