Biochemical and histological alterations following experimental lead poisoning

B. Nehru, S. Kaushal

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Chronic lead administration leads to serious impairment of renal function. In order to study the underlying mechanisms, the changes in whole kidney and renal brush border enzymes-namely, alkaline phosphatase and succinic dehydrogenase-were estimated both after short-term exposures of 15 days and prolonged administration of 2 and 3 months. Lead acetate as 5 mg, 10 mg and 50 mg/kg body weight, was administered in a single dose orally on every alternate day. A significant decrease in the activity of alkaline phosphatase was seen initially when lead was given for 15 days, but following prolonged administration the activity increased. Similarly, succinic dehydrogenase activity decreased initially when lead was given for a shorter duration (15 days), but after 2 and 3 months of exposure, the values increased significantly. Histopathological observations revealed renal proliferation and degeneration occurring at a high dose of lead acetate (50 mg/kg body weight). The enzymatic findings imply that an adaptive mechanism comes into play at the two higher levels of lead exposure.

Original languageEnglish (US)
Pages (from-to)203-209
Number of pages7
JournalJournal of Trace Elements in Experimental Medicine
Volume4
Issue number4
StatePublished - 1991
Externally publishedYes

Fingerprint

Industrial poisons
Lead Poisoning
Kidney
Succinate Dehydrogenase
Alkaline Phosphatase
Body Weight
Brushes
Microvilli
Lead
Enzymes

ASJC Scopus subject areas

  • Biochemistry

Cite this

Biochemical and histological alterations following experimental lead poisoning. / Nehru, B.; Kaushal, S.

In: Journal of Trace Elements in Experimental Medicine, Vol. 4, No. 4, 1991, p. 203-209.

Research output: Contribution to journalArticle

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